June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Enhanced Vitreal Imaging of the Vitreoretinal Interface in Normal Eyes Using Swept-Source OCT
Author Affiliations & Notes
  • Jonathan Liu
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Andre Witkin
    New England Eye Center, Tufts Medical Center, Boston, MA
  • Mehreen Adhi
    New England Eye Center, Tufts Medical Center, Boston, MA
  • Ireneusz Grulkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Martin Kraus
    Pattern Recognition Lab and Graduate School in Advanced Optical Technologies, University of Erlangen-Nuremburg, Erlangen, Germany
  • Chen Lu
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Joachim Hornegger
    Pattern Recognition Lab and Graduate School in Advanced Optical Technologies, University of Erlangen-Nuremburg, Erlangen, Germany
  • Jay Duker
    New England Eye Center, Tufts Medical Center, Boston, MA
  • James Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Footnotes
    Commercial Relationships Jonathan Liu, None; Andre Witkin, None; Mehreen Adhi, None; Ireneusz Grulkowski, None; Martin Kraus, Optovue Inc. (P); Chen Lu, None; Joachim Hornegger, Optovue Inc. (P) (P); Jay Duker, Carl Zeiss Meditech (F), OptoVue (F), Optos (C); James Fujimoto, Carl Zeiss Meditec (P), Optovue (P), Optovue (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3167. doi:https://doi.org/
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    • Get Citation

      Jonathan Liu, Andre Witkin, Mehreen Adhi, Ireneusz Grulkowski, Martin Kraus, Chen Lu, Joachim Hornegger, Jay Duker, James Fujimoto; Enhanced Vitreal Imaging of the Vitreoretinal Interface in Normal Eyes Using Swept-Source OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3167. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To demonstrate enhanced vitreal imaging (EVI) of the vitreoretinal interface using three-dimensional (3D) swept-source optical coherence tomography (SS-OCT) in normal subjects..

 
Methods
 

22 subjects with normal vision and no history of retinal disease, optic nerve abnormalities, or ocular surgery were included in this study. One randomly selected eye for each subject was imaged using a prototype 1050nm SS-OCT system with 6µm resolution, 3.6mm imaging range, and 100kHz axial scan rate. Up to eight orthogonal raster scanned volumes were acquired for each eye over 12mm×12mm retinal area (~40°) with 500×500 axial scans. The acquisition time per volume was <3 seconds. A registration algorithm was applied to remove motion artifacts and merge multiple volumes into a single dataset with improved signal. Enhanced vitreal imaging (EVI) was performed by adjusting threshold and contrast in the merged volumetric data.

 
Results
 

We obtained motion-corrected 3D OCT datasets from 22 normal eyes. Standard image display enabled visualization of retinal and deep choroidal features. Features observed with EVI include vitreous separation from the retina (18 eyes, 81.8%), hyaloid detachment near the optic nerve head (13 eyes, 59.1%), Bergmeister papilla (6 eyes, 27.3%), posterior precortical vitreous pocket (15 eyes, 68.2%), space of Martegiani (15 eyes, 68.2%), vitreous strands (13 eyes, 59.1%), and cellular aggregation (11 eyes, 50%).

 
Conclusions
 

Swept-source OCT with motion correction and EVI provides wide-field 3D information about vitreous structure, enabling detailed observations of the vitreoretinal interface. SS-OCT has an advantage over SD-OCT for vitreal imaging because it maintains high sensitivity over a long imaging range. The high speed of SS-OCT combined with motion correction and merging enables wide-field volumetric imaging. This method could be useful for imaging the 3D structure of the vitreous in patients with disorders of the vitreomacular interface, as well as assessing treatment response after vitrectomy or pharmaceutical vitreolysis.

 
 
3D SS-OCT imaging of the vitreous. A.Wide-field OCT fundus image. B.Center frame with standard display. C.Center frame with enhanced vitreal imaging (EVI) by adjusting threshold and contrast. Blue asterisk-posterior precortical vitreous pocket. Red arrow-hyaloid adhesion at the optic nerve region. Yellow asterisk-space of Martegiani. Green arrows-vitreous separation.
 
3D SS-OCT imaging of the vitreous. A.Wide-field OCT fundus image. B.Center frame with standard display. C.Center frame with enhanced vitreal imaging (EVI) by adjusting threshold and contrast. Blue asterisk-posterior precortical vitreous pocket. Red arrow-hyaloid adhesion at the optic nerve region. Yellow asterisk-space of Martegiani. Green arrows-vitreous separation.
 
Keywords: 763 vitreous • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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