June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
IMPROVEMENTS IN THE MODIFIED OSTEO-ODONTO KERATOPROSTHESIS (MOOKP) SURGERY TECHNIQUE
Author Affiliations & Notes
  • Mariela Aguilar
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Yoh Sawatari
    Oral Maxillofacial Division, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL
  • Alex Gonzalez
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • William Lee
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Cornelis Rowaan
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Deepa Sathiah
    Oral Maxillofacial Division, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL
  • Darlene Miller
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Victor Perez
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Eduardo Alfonso
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Footnotes
    Commercial Relationships Mariela Aguilar, None; Yoh Sawatari, University of MIami (P); Alex Gonzalez, None; William Lee, None; Cornelis Rowaan, None; Deepa Sathiah, None; Darlene Miller, None; Victor Perez, Alcon (C), Bausch & Lomb (C), Genentech (C), Cleveland Clinic Foundation (P), Alcon (F), Alcon (R); Eduardo Alfonso, Bio Tissue (C); Jean-Marie Parel, CROMA (F), InnFocus (F), Abeamed (F), University of Miami (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3481. doi:https://doi.org/
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      Mariela Aguilar, Yoh Sawatari, Alex Gonzalez, William Lee, Cornelis Rowaan, Deepa Sathiah, Darlene Miller, Victor Perez, Eduardo Alfonso, Jean-Marie Parel; IMPROVEMENTS IN THE MODIFIED OSTEO-ODONTO KERATOPROSTHESIS (MOOKP) SURGERY TECHNIQUE. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3481. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess the long-term effectiveness of 3 bonding agents that are periodically subjected to high static pressures on the optical cylinder face mimicking traumatic ocular incidents, and to develop an autoclavable µ-milling device designed to contour and drill the MOOKP lamina in an efficient and precise manner.

 
Methods
 

An instrument was fabricated to stabilize the lamina and apply direct pressure to the cemented optical cylinder. The strengths of cyanoacrylate adhesive (Histoacryl), a 2-part bone cement (Stryker), and the dental acrylic (Jet) were compared. 4 laminas per agent preserved at 36°C in 30cc of BSS with antibiotic (gatifloxacin 2µg/cc) and antifungal (amphotericin B 0.2mg/cc) for >12 months were subjected monthly to static forces ranging from 200g, 500g, and 1kg (1kg force = 200mmHg IOP equivalent). The force range was expanded to include 2kg and 3kg at month 13. An autoclavable µ-mill was developed to adapt a commercially available Stryker drill; using extracted canines, laminas were fashioned while monitoring internal temperatures via two thermocouples.

 
Results
 

All 12 laminas resisted the applied static forces corresponding to pressures of 2, 5 and 10kg/cm2 and the 30kg/cm2 applied at month 13. The µ-mill performance was tested on resected cadaveric lamina specimens. Planar surfaces are better than 50µm, perpendicularity is better than 1 degree; drilling departure from ovality is less than 10µm assuring excellent fit with the optical cylinder. The µ-mill was shown to be as efficacious as the manual technique, as it took less than 10 min to create a lamina. Moreover, the canine’s canal temperature never exceeded 38°C whereas with the manual technique, it exceeded 69°C which is higher than bone’s denaturation temperature.

 
Conclusions
 

There was no difference in the effectiveness of the 3 bonding agents at 13 months. A dynamic stress test will be necessary to differentiate between the bonding agents. The µ-mill keeps the temperature below the denaturation temperature and thus is safer than the manual technique. These two new observations can improve the MOOKP surgery technique. Acknowledgments: The authors acknowledge the scientific contributions of Giancarlo Falcinelli and Andres Bernal.

 
 
Instrument fabricated to stabilize the lamina and apply direct pressure to the cemented optical cylinder.
 
Instrument fabricated to stabilize the lamina and apply direct pressure to the cemented optical cylinder.
 
 
Autoclavable µ-milling device.
 
Autoclavable µ-milling device.
 
Keywords: 575 keratoprostheses • 467 clinical laboratory testing  
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