June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Analysis of hematological and biochemical data in normal tension glaucoma patients
Author Affiliations & Notes
  • Morio Ueno
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Yoko Ikeda
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Kengo Yoshii
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Haruna Yoshikawa
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Yuko Maruyama
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Kazuhiko Mori
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Kei Tashiro
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Shigeru Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3501. doi:
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      Morio Ueno, Yoko Ikeda, Kengo Yoshii, Haruna Yoshikawa, Yuko Maruyama, Kazuhiko Mori, Kei Tashiro, Shigeru Kinoshita; Analysis of hematological and biochemical data in normal tension glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3501.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Recent studies have shown that normal tension glaucoma (NTG) patients have more systemic disease compared with normal subjects. The purpose of this present study was to analyze the hematological and biochemical data of NTG patients and normal control subjects, and then compare the differences between those two sets of data.

Methods: This study involved 519 NTG patients (NTG group; 259 females and 260 males, mean age: 61.7±10.9 years) and 438 age-matched normal controls (NC group; 220 females and 218 males, mean age: 62.4±7.2 years) who consulted at the Glaucoma Clinic of Kyoto Prefectural University of Medicine, Kyoto, Japan. Hematological and biochemical data (23 parameters) were analyzed and compared between the two groups using the Welch's t test. Bonferroni’s correction was performed, and a p-value of <0.002 was considered statistically significant. In addition, a comparison between the females and males of both groups, respectively, was performed.

Results: Of the 23 parameters, a significant difference was found in the following 6 parameters: Lactate Dehydrogenase (LDH), total protein (T-Pro), albumin (Alb), glucose, triglyceride, mean corpuscular hemoglobin concentration (MCHC), and platelet counts (Plt). LDH, T-Pro and Plt were found to be significantly higher in the NTG group than in the NC group. There were significant differences in LDH and MCHC with females and LDH and triglyceride with males, respectively.

Conclusions: The findings of this study show that NTG patients have significant differences in the multiple parameters of blood serum data compared with age-matched normal control subjects.

Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment  
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