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ANDREA GOVETTO, Ramón Domínguez Fernández, Maria Luisa Landaluce, Maria Teresa Alves Perez, Ramon Lorente; Prevalence of Open-angle glaucoma in Vitrectomized Eyes. The PR.O.V.E study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3502.
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To estimate the prevalence of open-angle glaucoma (OAG) after uncomplicated pars plana vitrectomy (PPV).
A retrospective chart review of all patients who underwent PPV at our institution from January 2006 to January 2012 was made. Patients operaded due to eye trauma, penetrating injuries, endophthalmitis, uveitis and those who have preexisting glaucoma were excluded from the study. Telephone calls were made to all eligible patients. Those who accepted to partecipate were invited to the Ourense University Hospital for a comprehensive ophthalmic assessment, including best corrected visual acuity testing, applanation tonometry, gonioscopy, disc assessment, and Spectral-domain OCT scans of optic discs. The diagnosis of OAG was made based on standardized criteria modified from those used by the Rotterdam Study and Foster and associates.
Of 410 eligible patients, 174 accepted to participate to the study. 18 patients did not complete the ophthalmic assessment. In total, we evaluated 163 vitrectomized and 143 non-vitrectomized eyes of 156 patients. Of 163 vitrectomized eyes, 15 ( 8,9% ) developed OAG. Of 143 non-vitrectomized eyes, only 3 ( 2% ) develop OAG. This difference was statistically significant ( p= 0,02 ). We also compared the cup-to-disc ratio ( CDR ) and vertical cup-to-disc ratio ( VCDR ) of vitrectomized and non-vitrectomized eyes of 92 patients, obtained by Spectral-domain OCT. For this analysis we excluded all patients who underwent PPV in both eyes. In vitrectomized eyes, mean CDR was 0,32 ( ±1,8 ) while mean VCDR was 0,56 ( ± 1,8 ). In non-vitrectomized eyes, mean CDR was 0,28 ( ± 1,5 ) while mean VCDR was 0,51 ( ± 1,6 ). This difference did not reach statistical significance.
In our study the prevalence of OAG in vitrectomized eyes was higher compared to non-vitrectomized eyes. This difference was statistically significant.
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