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Ronnie George, Rashima Dinesh, Manish Panday, Ramesh S Ve, Vijaya Lingam; Comparison of the sensitivity and specificity of the Von Herick test and ocular biometric parameters as screening tests in prevalent and incident angle closure disease in a population based study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3520.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the diagnostic ability of the von Herick test and central anterior chamber depth in the detection of angle closure disease in a population based study in South India and in incident angle closure disease diagnosed 6 years later.
6815 participants in the Chennai Glaucoma Study, a population based study in South India, who were bilaterally phakic at the baseline evaluation were included. When they were re-examined 6 years following the baseline evaluation during the Chennai Eye Diseases Incidence Survey 3350 of them who were bilaterally phakic examined were included. Those with a diagnosis of angle closure disease at baseline were excluded. All participants underwent a comprehensive eye examination at both visits that included limbal chamber depth assessment and gonioscopy. A random subset of normal individuals and all those with angle closure disease underwent ultrasound biometry at baseline, all participants in CEDIS underwent biometry. The AUROC was calculated for the von Herick test , axial length, lens thickness and central anterior chamber depth at baseline and during the follow up visit.
At the baseline visit the AUROC for a Von Herick grade of 2 or less was0.89(95%CI:0.876,0.904) with a sensitivity of 79.5% and specificity of 91.9%. For axial length 0.717(95%CI: 0.692,0.741), central anterior chamber depth 0.865(95%CI:0.848,0.882) and lens thickness 0.60(95%CI: 0.571,0.629). For incident cases the AUROC for a Von Herick grade of 2 or less was0.684(95%CI:0.642,0.727) . For axial length 0.627(95%CI: 0.581,0.673), central anterior chamber depth 0.732(95%CI:0.690,0.774) and lens thickness 0.653(95%CI: 0.607,0.700).
Both limbal chamber depth and central anterior chamber depth were less effective at detecting incident as compared to prevalent angle closure disease in a population based study.
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