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Temple Rowe; An Anterior Chamber Optical Tissue Phantom for AC-OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3572.
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© ARVO (1962-2015); The Authors (2016-present)
To develop and test a model eye with a corneal tissue phantom that mimics changes in index of refraction and backscatter coefficients as closely as possible to normal human anatomy. The primary use of such a model is to provide a target to demonstrate capabilities of anterior chamber OCT instruments, as well as Scheimpflug cameras.
Three (3) AC model eyes were constructed and tested with a variety of OCT instruments. Values evaluated include central corneal thickness (CCT), and corneal stroma backscatter, two initial key values in the emulation of the human cornea from an OCT perspective. Values were measured by imagery taken from both a laboratory OCT and a commercial instrument.
On the AC-OCT we tested this with, the CCT was over-reported on average by 6%. Also, stromal backscatter signal in the model corneal did not match well with the backscatter measured from normal human cornea as measured by both the laboratory and commercial OCTs. See Figure 1, attached.
These initial attempts in emulation of a human cornea for use in demonstrating laboratory and commercial grade AC OCT instruments demonstrate the challenges of obtaining the goal of good tissue emulation. Results show the work necessary to emulate the stroma backscatter more accurately in these models, as well as understand some of the posterior cornea (endothelium) curvature variations from measured normal anatomy.
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