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cyntia solis, Stephanie Voorduin, Francisco Martinez, Teresa Valdez; Anterior Segment Fluorescein Angiography Findings in Patients with Fuchs’ Heterochromic Iridocyclitis compared with Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3579.
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To demonstrate changes in the vasculature in patients with Fuchs’ Heterochromic Iridocyclitis (FHI) with brown iris using anterior segment fluorescein angiography compared with normal controls.
Prospective descriptive, comparative, interventional study. Participants: A total of 10 patients (20 eyes) between July and September 2012. Patients had the following inclusion criteria: 1.- Complete clinical records 2.- Diagnosis of FHI 3.- Written informed consent. Controls had the following inclusion crietria: 1.- No ocular or systemic disease 2.- Written informed consent. Patients with any concomitant ocular disorder were excluded from the study. All patients underwent an anterior segment fluorescein angiography in both eyes using a convenctional technique. All studies were evaluated by the same observer (CS) to determine any abnormalities in the study.
Of the 10 patients included, all had brown iris, 9 had leakage or abnormal vessels in the iris stroma or the pupillary margin in at least one quadrant in both eyes compared with none of the 3 healthy controls.
There are very few reports regarding anterior segment fluorescein angiography in patients with FHI, to our knowledge this is the largest series. An interesting finding of our study is that the eye without a clinical diagnosis of FHI also showed altered iris vasculature. None of the healthy controls showed any changes in the study. This study demostrate that patients with FHI have an abnormal blood -aqueous barrier, but maybe this isn’t the only mechanism implied in the pathogenesis of the disease.
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