Abstract
Purpose:
The purpose of this study, with ”En Face” OCT was to evaluate reproducibility of a recent software for segmentation of the retina to recognize during post treatment follow up either the fibrosis of choroidal neovascular network or the recurrence or persistence of exudation.
Methods:
49 patients with FV-PED in macular degeneration (AMD) treated with intravitreal injection of Ranibizumab (PRN)and followed up during one year were included. Diagnosis was suggested on: FA+ICGA+SD-OCT (Spectralis, Heidelberg Engineering, Germany).Volume acquisition (97 EDI-OCT sections of 9 averaged B-scans at 30 µm intervals, generating 496 C-scans), was obtained, in 60 seconds. The image was cropped on ICG to confirm the neovascularization. Reproducibility intra and inter observer were evaluated (2 senior observers).
Results:
Reproducibility intra and inter observer were 98% and 94% with “en face” OCT versus B- Scan OCT. After one year treatment with anti VEGF Injections, the branching network with small ramifications was detectable only if there is still subretinal fluid. The hyper-reflective course of type 1 CNV is progressively masked due to progressive fibrosis of the FV-PED. Fluid accumulation was present at inclusion, in all 49 FV PED. At one year, presence of fluid was doubtful or not detected on B-Scan in 16/49 cases. On C- Scan, presence fluid was recognized, easily detectable, in 10 cases. C-Scan disclosed extension or recurrence, in 6 other cases
Conclusions:
C -Scan OCT, during follow up, allows easy detection of the recurrence or persistence of exudation, even easier and better than B-Scan OCT. This new “En Face” OCT technology allows to visualize the contours and the shape of the FV-PED, the choroid neovascular network in the FV-PED without dye. “En Face” SD-OCT demonstrates for the first time, directs signs of choroidal neovascularization, allows overlay and measurement of area of lesion of fibrovascular PED. Disclosure: None
Keywords: 412 age-related macular degeneration •
552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) •
701 retinal pigment epithelium