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SUQIN YU; Outer retinal structure in OCT and microperimetry. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3601.
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© ARVO (1962-2015); The Authors (2016-present)
To study the microperimetry in patients with abnormal structure of outer retinal layer in OCT.
33 cases of 53 eyes that found abnormal outer retinal structures in fourier-domain optical coherence tomography (FD-OCT) were performed microperimetry (MP-1). Local retinal sensitivity was measured and fixation status was evaluated. The relation between structure impairment and local retinal function was studied.
Fundus photography and fundus fluorescence angiography showed atrophy or depigmentation changes without any bleeding,exudation,intra- or sub-retinal fluid in these cases. With high-resolution Fourier-domain OCT, lesions were found mainly impair the retinal outer layers without edema or fluid accumulation. There is a certain relation between the change of outer retinal structure and visual function. Cases in this group show that even the inner retinal structure is intact, outer structure abnormalities may lead to decreased local retinal sensitivity. Cases in which macular involved show that even the band of outer nuclear layer is intact, the discontinuity of Ellipsoid Zone, previously known as IS / OS, may result in central vision impairment. PRE atrophy may contribute to irreversible damage of visual function.
Fourier-domain OCT cannot only learn the details of outer retina structure, but may also predict the visual function of patients. It can play an important role in disease nature history follow-up,clinical therapeutic effects observation and visual rehabilitation training.
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