June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Assessment of Cirrus™ OCT Registration in Macular Edema from Diabetes or Retinal Vein Occlusion
Author Affiliations & Notes
  • Voraporn Chaikitmongkol
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
    Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand
  • Mary Durbin
    Carl Zeiss Meditec Inc., Dublin, CA
  • Susan Bressler
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Neil Bressler
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships Voraporn Chaikitmongkol, None; Mary Durbin, Carl Zeiss Meditec, Inc. (E); Susan Bressler, Novartis (F), Bausch and Lomb (F), Genentech (F), Thrombogenics (F), Lumenis (F), Notal vision (F), GlaxoSmithKline (C), allergan (F); Neil Bressler, Abbott Medical Optics, inc (F), Alimera Sciences (F), Allergan (F), Bausch &Lomb, Inc (F), Bayer (F), Carl Zeiss Meditec, Inc (F), ForSight Labs, LLC (F), Genentech, Inc (F), Genzyme Corporation (F), Lumenis, Inc (F), Notal VIsion (F), Novartis Pharma AG (F), Pfizer, Inc (F), Regeneron Pharmaceuticals, Inc (F), Roche (F), Thrombogencis (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3617. doi:
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      Voraporn Chaikitmongkol, Mary Durbin, Susan Bressler, Neil Bressler; Assessment of Cirrus™ OCT Registration in Macular Edema from Diabetes or Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3617.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Spectral domain optical coherence tomography (SD-OCT) enables registration of OCT images with fundus landmarks which may facilitate management decisions when comparing OCTs in the same region across visits. Registration software in SD-OCTs, thus, can be used to evaluate treatment response of macular edema due to diabetes (DME), branch or central retinal vein occlusion (BRVO or CRVO). This project evaluated the Cirrus™ (Carl Zeiss Meditec, California) SD-OCT registration software (utilizing post-image acquisition warping) in cases of macular edema.

Methods: Patients diagnosed with DME or ME due to RVOs from January 2011 to June 2012 by two retina specialists (SBB, NMB) at a university-based center were identified from retrospective review of billing and electronic medical records. Patients with Cirrus™ SD-OCTs during at least 2 visits were included. Macular thickness analyses (macular cube 512 x 128 scan) of the 1st and 2nd visit were reviewed. Automatic and manual registrations were obtained using the Macular Change Analysis program. Registration quality was graded as perfect, good, acceptable, or poor.

Results: 56 eyes (44 patients) with DME (86%), BRVO (9%), and CRVO (5%) were included. Mean baseline central subfield (CSF) thickness (±SD) was 355±105 um. Automatic registration by the instrument software succeeded in 39 eyes (70% [95% confidence interval {CI}: 58% to 82%]), and failed in 17 eyes (30%). Among the successful automatic registrations, the quality was perfect in 15%, good in 41%, acceptable in 33%, and poor in 10%. Among the 17 eyes that failed automatic registration, manual registration succeeded in 16 (94% [95% CI: 84% to 100%]) among which 2 were good, 11 were acceptable, and 3 were poor. Only 1 eye (6%) in this subgroup showed >10% difference when comparing percent thickness change of the central subfield “raw non-registered” and “manually registered” data.

Conclusions: Automatic registration with Cirrus™ SD-OCT software appears to be successful in 58% to 82% of patients being managed for ME from diabetes or retinal vein occlusion, and most have at least acceptable quality. Manual registration can be obtained in nearly all cases that fail automatic registration, although the quality of the registration may be suboptimal. When manual registration was required, the CSF value in the revised thickness change map rarely changed by at least 10%.

Keywords: 550 imaging/image analysis: clinical • 498 diabetes • 505 edema  

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