June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Three-Dimensional Biometric Measurements of Accommodation Using Full-Eye-Length Swept-Source OCT
Author Affiliations & Notes
  • Ireneusz Grulkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Jonathan Liu
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Benjamin Potsaid
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
    Advanced Imaging Group, Thorlabs Inc., Newton, NJ
  • Vijaysekhar Jayaraman
    Praevium Research Inc., Santa Barbara, CA
  • Alex Cable
    Advanced Imaging Group, Thorlabs Inc., Newton, NJ
  • Martin Kraus
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
    Pattern Recognition Lab and Graduate School in Advanced Optical Technologies (SAOT), University Erlangen-Nuremburg, Erlangen, Germany
  • Joachim Hornegger
    Pattern Recognition Lab and Graduate School in Advanced Optical Technologies (SAOT), University Erlangen-Nuremburg, Erlangen, Germany
  • Jay Duker
    New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, OR
  • James Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA
  • Footnotes
    Commercial Relationships Ireneusz Grulkowski, None; Jonathan Liu, None; Benjamin Potsaid, Thorlabs, Inc. (E), Optovue, Inc. (P); Vijaysekhar Jayaraman, Praevium Research, Inc. (E), Thorlabs, Inc. (F); Alex Cable, None; Martin Kraus, Optovue Inc. (P); Joachim Hornegger, Optovue Inc. (P) (P); Jay Duker, Carl Zeiss Meditech (F), OptoVue (F), Optos (C); David Huang, Optovue (F), Optovue (I), Optovue (P), Optovue (R), Carl Zeiss Meditec (P); James Fujimoto, Carl Zeiss Meditec (P), Optovue (P), Optovue (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 381. doi:
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      Ireneusz Grulkowski, Jonathan Liu, Benjamin Potsaid, Vijaysekhar Jayaraman, Alex Cable, Martin Kraus, Joachim Hornegger, Jay Duker, David Huang, James Fujimoto; Three-Dimensional Biometric Measurements of Accommodation Using Full-Eye-Length Swept-Source OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):381.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To demonstrate high speed, long-range swept source OCT utilizing vertical cavity surface emitting laser (VCSEL) technology for in vivo dynamic three-dimensional (3-D) imaging of eyes during accommodation. To measure changes in biometric parameters of the cornea and crystalline lens and determine changes in intraocular distances during accommodation.

 
Methods
 

A high speed swept-source OCT instrument for long-range imaging was developed and integrated with Badal optometer for investigating accommodation. Full-eye-length imaging at 1050 nm with 100 kHz axial scan rate and 39 mm depth range was performed on five eyes (5 subjects, age 28.4±5.6 yrs, mean spherical equivalent -3.2±2.7 D) at 4 different vergence levels (0 D, 2 D, 4 D and 6 D). OCT volumetric data sets scanned with orthogonal rasters were registered and refraction corrected to remove both motion artifacts and distortion from light refraction. Measurements of parameters in the eye were calculated including central corneal thickness, anterior chamber depth, lens thickness, vitreous depth, axial length, as well as corneal curvature and crystalline lens curvature.

 
Results
 

Volumetric OCT data spanning the depth of the entire eye for 3-D visualization and measurement of anterior chamber morphometry and axial eye length during accommodation were obtained. No significant change of the central corneal thickness or axial eye length was observed during accommodation. Increased accommodation demand caused movement of the crystalline lens toward the cornea, which resulted in decreased anterior chamber depth. The crystalline lens became thicker during accommodation, and its anterior and posterior curvatures change significantly compared with the unaccommodated eye. The iris also became more constricted at higher accommodation demand levels.

 
Conclusions
 

3-D Full eye length swept source OCT enables the measurement of comprehensive quantitative biometric information on the anterior segment of the eye as well as eye length during accommodation. This technology and method promises to be a useful tool for studying the mechanisms of accommodation and presbyopia as well as for developing next generation accommodating or multifocal IOLs in the future.

  
Keywords: 404 accommodation • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 421 anterior segment  
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