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Ireneusz Grulkowski, Jonathan Liu, Benjamin Potsaid, Vijaysekhar Jayaraman, Alex Cable, Martin Kraus, Joachim Hornegger, Jay Duker, David Huang, James Fujimoto; Three-Dimensional Biometric Measurements of Accommodation Using Full-Eye-Length Swept-Source OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):381.
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To demonstrate high speed, long-range swept source OCT utilizing vertical cavity surface emitting laser (VCSEL) technology for in vivo dynamic three-dimensional (3-D) imaging of eyes during accommodation. To measure changes in biometric parameters of the cornea and crystalline lens and determine changes in intraocular distances during accommodation.
A high speed swept-source OCT instrument for long-range imaging was developed and integrated with Badal optometer for investigating accommodation. Full-eye-length imaging at 1050 nm with 100 kHz axial scan rate and 39 mm depth range was performed on five eyes (5 subjects, age 28.4±5.6 yrs, mean spherical equivalent -3.2±2.7 D) at 4 different vergence levels (0 D, 2 D, 4 D and 6 D). OCT volumetric data sets scanned with orthogonal rasters were registered and refraction corrected to remove both motion artifacts and distortion from light refraction. Measurements of parameters in the eye were calculated including central corneal thickness, anterior chamber depth, lens thickness, vitreous depth, axial length, as well as corneal curvature and crystalline lens curvature.
Volumetric OCT data spanning the depth of the entire eye for 3-D visualization and measurement of anterior chamber morphometry and axial eye length during accommodation were obtained. No significant change of the central corneal thickness or axial eye length was observed during accommodation. Increased accommodation demand caused movement of the crystalline lens toward the cornea, which resulted in decreased anterior chamber depth. The crystalline lens became thicker during accommodation, and its anterior and posterior curvatures change significantly compared with the unaccommodated eye. The iris also became more constricted at higher accommodation demand levels.
3-D Full eye length swept source OCT enables the measurement of comprehensive quantitative biometric information on the anterior segment of the eye as well as eye length during accommodation. This technology and method promises to be a useful tool for studying the mechanisms of accommodation and presbyopia as well as for developing next generation accommodating or multifocal IOLs in the future.
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