June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Clinical characteristics of responders to intravitreal Bevacizumab in central serous chorioretinopathy patients
Author Affiliations & Notes
  • Gyu Ah Kim
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
  • Tyler Hyung Taek Rim
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
  • Christopher Lee
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
  • SungChul lee
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3850. doi:
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      Gyu Ah Kim, Tyler Hyung Taek Rim, Christopher Lee, SungChul lee; Clinical characteristics of responders to intravitreal Bevacizumab in central serous chorioretinopathy patients. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3850.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Bevacizumab has been reported to be effective in central serous chorioretinopathy(CSC). We investigated the clinical factors associated with response to intravitreal bevacizumab(IVB) in CSC patients.

 
Methods
 

We retrospectively reviewed the medical charts of 48 eyes of 48 patients with CSC who received IVB (0.05ml, 1.25mg) and followed up for at least 3 months from November 2009 through December 2012. “Good responder” was defined as complete resolution of subretinal fluid(SRF) on spectral domain optical coherence tomography(SD-OCT) within 1month following a single session of IVB. Eyes that showed partial or no resolution of SRF were grouped as “poor responder”. Subfoveal choroidal thickness and basal diameter of detached retina were measured on SD-OCT. Number of leakage sites, distance of leaking point from foveal center, and CSC type classification (“classic” or “diffuse retinal pigment epitheliopathy”) were analyzed using fluorescein angiography(FA).

 
Results
 

There were 10 (20.8%) good responders and 38 (79.2%) poor responders. The mean follow-up was 4.3months. No significant difference was noted between the 2 groups with respect to demographic characteristics including age, gender, and spherical equivalent except preoperative visual acuity(p<0.01). There was no statistical difference between 2 groups with respect to CSC types, number of leakage sites, and distance to the nearest leakage site. The largest basal diameter of detached retina was significantly smaller in good responders than poor responders (1215±383µm vs. 1605±469µm; p=0.03). Subfoveal choroidal thickness was significantly thicker in good responders than poor responders (485.0±104.2µm vs. 379.2± 137.5µm; p=0.04). According to receiver operator characteristic(ROC) analysis, subfoveal choroidal thickness was characteristic parameter of good responder with area under the curve of 0.74. The cut-off value of 434µm were determined by ROC curve with 77.8% sensitivity and 70.0% specificity. Subjects with ≥434µm of choroidal thickness were more likely to be a good responder (Odds ratio = 5.43, 95CI, 1.06-27.8).

 
Conclusions
 

We found that thicker choroid and smaller basal diameter of the detached retina in CSC predict good response to IVB. This may imply an important role of choroid in CSC.

 
Keywords: 585 macula/fovea • 701 retinal pigment epithelium • 452 choroid  
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