June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
A Standardized Regimen for Extended-Wear Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE): Treatment of Persistent Epithelial Defects
Author Affiliations & Notes
  • Jessica Ciralsky
    Weill Cornell, New York, NY
  • Kristin Chapman
    Weill Cornell, New York, NY
  • Michelle Lee
    Weill Cornell, New York, NY
  • Mark Rosenblatt
    Weill Cornell, New York, NY
  • Priyanka Sood
    Weill Cornell, New York, NY
  • Ana Alzaga Fernandez
    Weill Cornell, New York, NY
  • Kimberly Sippel
    Weill Cornell, New York, NY
  • Footnotes
    Commercial Relationships Jessica Ciralsky, None; Kristin Chapman, None; Michelle Lee, None; Mark Rosenblatt, None; Priyanka Sood, None; Ana Alzaga Fernandez, None; Kimberly Sippel, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3909. doi:https://doi.org/
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      Jessica Ciralsky, Kristin Chapman, Michelle Lee, Mark Rosenblatt, Priyanka Sood, Ana Alzaga Fernandez, Kimberly Sippel; A Standardized Regimen for Extended-Wear Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE): Treatment of Persistent Epithelial Defects. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3909. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe a standardized regimen for the treatment of persistent corneal epithelial defects in patients with severe ocular surface diseases with extended-wear Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE).

Methods: Retrospective review of nine eyes of eight patients with persistent epithelial defects treated with a standardized extended-wear PROSE regimen. PROSE was worn 24 hours a day until at least 48 hours after complete corneal re-epithelialization was achieved. Device removal, device cleaning, disinfection, and replacement of the fluid reservoir were performed daily. A BAK-free fourth-generation quinolone antibiotic drop was added to the fluid reservoir for all patients.

Results: All eight patients had complete resolution of the persistent epithelial defects and noted improvement in ocular symptoms. None of the patients developed microbial keratitis or recurrent epithelial defects.

Conclusions: Extended-wear PROSE, using our standardized regimen, is an effective and safe treatment option for persistent epithelial defects in severe ocular surface diseases.

Keywords: 482 cornea: epithelium • 765 wound healing • 486 cornea: tears/tear film/dry eye  
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