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Jessica Ciralsky, Kristin Chapman, Michelle Lee, Mark Rosenblatt, Priyanka Sood, Ana Alzaga Fernandez, Kimberly Sippel; A Standardized Regimen for Extended-Wear Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE): Treatment of Persistent Epithelial Defects. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3909. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To describe a standardized regimen for the treatment of persistent corneal epithelial defects in patients with severe ocular surface diseases with extended-wear Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE).
Retrospective review of nine eyes of eight patients with persistent epithelial defects treated with a standardized extended-wear PROSE regimen. PROSE was worn 24 hours a day until at least 48 hours after complete corneal re-epithelialization was achieved. Device removal, device cleaning, disinfection, and replacement of the fluid reservoir were performed daily. A BAK-free fourth-generation quinolone antibiotic drop was added to the fluid reservoir for all patients.
All eight patients had complete resolution of the persistent epithelial defects and noted improvement in ocular symptoms. None of the patients developed microbial keratitis or recurrent epithelial defects.
Extended-wear PROSE, using our standardized regimen, is an effective and safe treatment option for persistent epithelial defects in severe ocular surface diseases.
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