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Marta Pazos, Alfonso Anton, Maria Jesus López-Valladares, Valentín Tinguaro Díaz-Alemán, Monica Fallon; Relationship between Corneal Hysteresis and Visual Field Progression in Glaucoma and Ocular Hypertensive Eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3948.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate if glaucomatous visual field progression is associated to corneal hysteresis parameters measured by the Ocular Response Analyzer (ORA).
One hundred glaucomatous and ocular hypertensive (OHT) patients previously analyzed for an ORA reproducibility study were prospectively evaluated in the basis of their standard follow-up care in the glaucoma clinic. Only patients with 3 years follow-up and a minimum of 5 Humphrey Standard 24-2visual fields (VF) were included. Guided Progression Analyzer (GPA) Visual Field Index (VFI) rate of progression (significant trend at p<0.05) and/or Progression Analysis Probability of events (three contiguous points significantly changing in at least two consecutive tests) were used to detect VF progression.
59 eyes (31 Glaucoma and 28 OHT, mean age 70.69±11.87 y; mean MD -2.95±4.7 dB; mean number of VF 8±2.45; mean follow-up time 4.10 ±0.64 y) met the enrolment criteria. The glaucoma group had significantly lower central corneal thickness (CCT) (531.42±30.9 vs 559.07±26.57μm, p<0.01) and lower corneal resistance factor (CRF) (9.16±1.61 vs 11.59±1.83, p<0.01) but not significantly different corneal hysteresis (CH) (8.66±2.16 vs 9.72±2.26, p=0.07) compared with the OHT group. The mean global VFI rate of progression was -0.57 ± 1.22 dB/year (Glaucoma:-1.05±1.5 vs OHT: -0.03±0.4 dB/year; p<0.01). Seventeen eyes reached a progression endpoint (2 in the OHT group and 15 in the Glaucoma group). Progressing eyes had greater baseline cup-to-disc ratio (0.66±0.2 vs 0.51±0.23; p<0.05), lower CCT (530±36.34 vs 550.4±36.3 μm; p<0.05) and lower CRF (9.31±1.27 vs; 10.72±2.25; p<0.05) but not significantly different CH (8.34±2.5 vs 9.50±2.1; p=0.07) compared with non-progressing eyes. Rate of progression, among progressing eyes, was significantly greater with decreasing CRF (r2 0.04, p<0.001).
Thinner CCT and lower CRF were associated with progressive field worsening in glaucomatous and OHT eyes.
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