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Ayako Yasui, Manabu Yamamoto, Takeya Kohno, tasuku yoneda, Yusaku Yoshida, Hisashi Iwami, Dirk Theisen-Kunde, Yoko Miura, Ralf Brinkmann, Kunihiko Shiraki; Focal Retinal Sensitivity Before and After Selective Retina Therapy for Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4130.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the changes in focal retinal sensitivity after Selective Retina Therapy (SRT) for central serous chorioretinopathy (CSCR).
A total of four eyes in four men with CSCR (mean age, 38 years; range, 29 to 49 years) who underwent SRT (Medical Laser Center Luebeck, Germany, Nd:YLF laser; 527nm wavelength, 1.7μs pulse duration, 100 Hz repetition rate) between April and October 2012 and for whom retinal sensitivity could be measured for three months after treatment were investigated. Retinal sensitivity was measured using the microperimetry (Macular Integrity Assessment, MAIA®, Topcon, Japan). We investigated changes in the mean retinal sensitivity threshold within the central 10° and changes in sensitivity at the SRT irradiation spots and test irradiation spots before and after treatment, as well as correlations between the laser pulse energy and optoacoustic value (OA) through optoacoustic signals that was developed as an indicator of RPE cell destruction from microbubble formation inside the RPE cells.
The mean retinal sensitivity within the central 10° increased from 22.2 dB preoperatively to 25.3 dB at one month and 26.4 dB at three months, while sensitivity at the lesion of SRT irradiation spots increased from 20.6 dB preoperatively to 23.7 dB at one month and 25.5 dB at three months, indicating significant postoperative improvements (P<0.001) at both spots in both time periods. At the test irradiation spots, retinal sensitivity significantly decreased (P<0.05) from 27.5 dB preoperatively to 26.4 dB at one month, whereas there was no more significant difference at three months (27.4 dB; P=0.89). While a correlation was observed between test irradiation energy and OA value (R=0.70, P<0.001), no correlation was observed between changes in sensitivity at the test irradiation spots and laser energy or OA value both after one month and three months periods (vs. energy; P=0.89 at one month, 0.06 at three months, OA value; P=0.67 at one month, 0.11 at three months).
Retinal sensitivity improved following SRT in both the macular area and at the SRT irradiation spots. Results of the test spots suggest that SRT-irradiated lesion may maintain its retinal function, and even slight decrease directly following the irradiation, recover its full retinal function at latest in 3 months without scotoma.
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