June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The evaluation of fundus auto-fluorescence ( FAF) patterns in patient’s with Geographic Atrophy( GA) and the correlation with visual acuity
Author Affiliations & Notes
  • Ina Jaurre
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Shama Mudhar
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Nitin Jain
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Michail Polyzos
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Geeta Menon
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Lorraine North
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Manju Chandran
    Eye treatment unit, Frimley Park Hospital, Frimley, Surrey, United Kingdom
  • Footnotes
    Commercial Relationships Ina Jaurre, None; Shama Mudhar, None; Nitin Jain, None; Michail Polyzos, None; Geeta Menon, NOVARTIS (R), ALLERGAN (R), BAYER (R); Lorraine North, None; Manju Chandran, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4152. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ina Jaurre, Shama Mudhar, Nitin Jain, Michail Polyzos, Geeta Menon, Lorraine North, Manju Chandran; The evaluation of fundus auto-fluorescence ( FAF) patterns in patient’s with Geographic Atrophy( GA) and the correlation with visual acuity. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4152. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: A one year retrospective study to assess the correlation between visual acuity and fundus auto-fluorescence ( FAF) patterns using region finder in patients with GA.

Methods: Patients with GA were analysed. All patients had best corrected visual acuity (BCVA) measured using ETDRS and FAF imaging. Using the region finder software on the Heidelberg Spectralis OCT, FAF patterns were measured in patients with GA. Image analysis for each patient helped formulate a graph of the change in area of GA over the year and this was then compared to the visual acuity.

Results: Retrospective analysis of 29 patients with GA was carried out.The average area of GA at baseline was 3.508 (± 3). At 6 months ± 1 month the average area of GA was 3.979 (± 2), this increased to 4.545 at 1 year. Two patients had large areas of GA at baseline The findings show that although there is a definite increase in area of atrophy in AF scans with dry AMD patients over time there is not always a decrease in vision.Our findings support previous studies that have shown that GA does increase in size with FAF scans.( Holz et al) The effect on vision remains inconclusive in relation to the area of GA in FAF scans at baseline to one year in this study. Extending the study to review patients at yearly intervals for 5 years may give us a better idea of the correlation with BCVA. with areas of 10.859 and 12.715 which affected the average. Overall 41.3% patients showed a decrease in BCVA of more than 4 letters over 12 months. Two patients showed an increase in BCVA. These patients had cataract extraction during the trial year and therefore their results were considered anomalous for the study.

Conclusions: The findings show that although there is a definite increase in area of atrophy in AF scans with dry AMD patients over time there is not always a decrease in vision.Our findings support previous studies that have shown that GA does increase in size with FAF scans.( Holz et al) The effect on vision remains inconclusive in relation to the area of GA in FAF scans at baseline to one year in this study. Extending the study to review patients at yearly intervals for 5 years may give us a better idea of the correlation with BCVA.

Keywords: 412 age-related macular degeneration • 688 retina • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×