June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Rod and Cone function and its relationship to OCT sub structural changes in Age-related Macular degeneration
Author Affiliations & Notes
  • Brighu Swamy
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Evan Wong
    Lions Eye Institute, Perth, WA, Australia
  • Simona Degli Esposti
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Keane
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    UCL Institute of Ophthalmology National Institute for Health Research Biomedical Research Centre, London, United Kingdom
  • Michael Crossland
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Dawn Sim
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Adnan Tufail
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    UCL Institute of Ophthalmology National Institute for Health Research Biomedical Research Centre, London, United Kingdom
  • Fred Chen
    Lions Eye Institute, Perth, WA, Australia
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4159. doi:
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    • Get Citation

      Brighu Swamy, Evan Wong, Simona Degli Esposti, Pearse Keane, Michael Crossland, Dawn Sim, Adnan Tufail, Fred Chen; Rod and Cone function and its relationship to OCT sub structural changes in Age-related Macular degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4159.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To better understand structure and functional relationships in early AMD. In this abstract, we analyze the optical coherence tomography (OCT) features of early AMD and correlate these findings with cone and rod function as measured by microperimetry.

 
Methods
 

Clinical and imaging data were collected from patients with dry AMD undergoing Spectral domain OCT and dark adapted microperimetry ( cone and rod function on Nidek MP1-s) and scotopic microperimetry (cone function MAIA microperimeter) . Custom image analysis software (OCTOR) was used for quantitative analysis segmentation of the retinal substructure . Retinal spaces quantified included retina, photoreceptor outer segments, RPE to choriocapillaris (i.e. drusen/PED). Segmented enface images were overlaid onto the microperimetry maps and descriptive data generated.

 
Results
 

12 patients underwent MPIS, MAIA and high density spectralis OCT. A subset of these patients underwent segmentation of the retinal layers and overlay of retinal sensitivity maps. The following regions were found to have relationship between functional deficit on testing and structural abnormalities. Ellipsoid zone and RPE to choriocapillaris thickness (drusen height). Area of normal values of RPE to choriocapillaris thickness (ie no confluent drusen or drusenoid PED) was associated with a median retinal sensitivity of 12.7dB (quartiles : 11dB, 14dB). The median retinal sensitivities were 7.4dB (quartiles: 7dB, 9dB) for sub RPE drusen.

 
Conclusions
 

Sub retinal drusen deposits is associated with reduced retinal sensitivities. Understanding structural markers that relate to rod and cone functional defecits amy help to better understand subtypes of early AMD and help develop novel clinical trial endpoints

 
 
Microperimetry (MP1S) functional map overlaid onto segmented OCT enface map illustrating RPE to choriocapillaris thickness (i.e. drusen/PED) . Pseudocolor map within the ETDRS zone represents thickness values. This shows reduced sensitivity in areas of significant drusen deposition.
 
Microperimetry (MP1S) functional map overlaid onto segmented OCT enface map illustrating RPE to choriocapillaris thickness (i.e. drusen/PED) . Pseudocolor map within the ETDRS zone represents thickness values. This shows reduced sensitivity in areas of significant drusen deposition.
 
Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical • 585 macula/fovea  
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