June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Reticular Pseudodrusen in Early Age-Related Macular Degeneration is Associated with Choroidal Thinning
Author Affiliations & Notes
  • Aakriti Garg
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Maris Oll
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Suzanne Yzer
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Rando Allikmets
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
    Pathology & Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY
  • Stanley Chang
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Gaetano Barile
    Ophthalmology, Manhattan Eye, Ear, & Throat Hospital, New York, NY
  • Roland Smith
    Ophthalmology, New York University Medical Center, New York, NY
  • John Merriam
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Stephen Tsang
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
    Pathology & Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY
  • Srilaxmi Bearelly
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, NY
  • Footnotes
    Commercial Relationships Aakriti Garg, None; Maris Oll, None; Suzanne Yzer, None; Rando Allikmets, None; Stanley Chang, Alcon Laboratories (C), Alimera Sciences (C); Gaetano Barile, PCAsso Diagnostics LLC (P), PCAsso Diagnostics LLC (I); Roland Smith, None; John Merriam, None; Stephen Tsang, None; Srilaxmi Bearelly, Kaplen Foundation (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4169. doi:https://doi.org/
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      Aakriti Garg, Maris Oll, Suzanne Yzer, Rando Allikmets, Stanley Chang, Gaetano Barile, Roland Smith, John Merriam, Stephen Tsang, Srilaxmi Bearelly; Reticular Pseudodrusen in Early Age-Related Macular Degeneration is Associated with Choroidal Thinning. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4169. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To compare subfoveal choroidal thickness (SFCT) measurements in early age-related macular degeneration (AMD) between patients with and without reticular pseudodrusen (RPD) using spectral-domain optical coherence tomography (SDOCT).

 
Methods
 

This cross-sectional study examined 84 AMD patients (40 RPD, 44 non-RPD) who were age- and gender-matched (RPD: 32 of 40 (80%) were female, mean age 76.9 years ± 7.5 SD; non-RPD: 32 of 44 (73%) were female, mean age 73.9 years ± 7.8 SD). 63 RPD eyes and 75 non-RPD eyes were included in the analysis. Exclusion criteria included late AMD (geographic atrophy greater than 500 microns2 or history of choroidal neovascularization), myopia greater than -6 diopters, central serous chorioretinopathy, or past vitreoretinal surgery. Color fundus photographs and scanning laser ophthalmoscopy (including autofluorescence and infrared imaging) were graded in a masked fashion by three retinal specialists (SY, SB, MO) to identify RPD and non-RPD groups. SDOCT was used to measure choroidal thickness for all eyes. For each eye, the best SDOCT image with a clear posterior margin of choroid was chosen for analysis. Enhanced depth imaging spectral-domain optical coherence tomography (EDI-SDOCT) was used when available (20 of 138 eyes). SFCT was measured using Heidelberg Eye Explorer interactive software.

 
Results
 

Mean SFCT of RPD eyes (176.3 microns ± 60.5 SD) was significantly less than that of non-RPD eyes (216.5 microns ± 70.3 SD) by the Student’s t-test for independent samples (p = 0.0005).

 
Conclusions
 

These results support previous smaller studies that have shown RPD is associated with a thinner choroid. As RPD has been associated with increased risk of advanced AMD, SFCT may be integral to understanding the RPD process, as well as stratifying risk of AMD progression.

 
 
Images of an AMD patient without RPD. EDI-SDOCT (top) shows a SFCT of 451 microns. Infrared (middle) and autofluorescence (bottom) imaging depict absence of RPD.
 
Images of an AMD patient without RPD. EDI-SDOCT (top) shows a SFCT of 451 microns. Infrared (middle) and autofluorescence (bottom) imaging depict absence of RPD.
 
 
Images of an AMD patient with RPD. SDOCT (top) shows a very thin SFCT of 32 microns. Infrared (middle) and autofluorescence (bottom) imaging support the presence of RPD throughout the fundus.
 
Images of an AMD patient with RPD. SDOCT (top) shows a very thin SFCT of 32 microns. Infrared (middle) and autofluorescence (bottom) imaging support the presence of RPD throughout the fundus.
 
Keywords: 412 age-related macular degeneration • 452 choroid • 464 clinical (human) or epidemiologic studies: risk factor assessment  
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