Purchase this article with an account.
Ferdinand Schlanitz, Bernhard Baumann, Matthias Bolz, Erich Gotzinger, Michael Pircher, Christoph Hitzenberger, Ursula Schmidt-Erfurth; Long-term evaluation of drusen area and volume using polarization-sensitive OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4171.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate drusen area and volume over time using polarization-sensitive OCT (PS-OCT).
30 Patients with drusen due to age-related macular degeneration were imaged using PS-OCT every 6 months over three years. Patients were followed until a regression of drusen (spontaneous or due to a development of advanced AMD) occurred. The drusen area and volume in each macular volume scan were evaluated using an automated segmentation algorithm based on the depolarization information of the PS-OCT.
In all eyes, a continuous and approximately linear increase of drusen area and volume was observed. Mainly, patients could be classified into two groups: Group A was characterized by a progression rate of more than 0.1 mm2 in area and 0.01mm3 in volume per six months (mean rate: 0.54mm2 resp. 0.03mm3, SD: 0.14 resp. 0.01, range 0.32 - 0.76 resp. 0.02 - 0.05), and Group B a progression rate below 0.1mm2 in area resp. 0.01mm3 in volume (mean rate: 0.08mm2 resp. 0.003mm3, SD: 0.02 resp. 0.001, range 0.06 - 0.1 resp. 0.002 - 0.004). The progression rates were significantly related to the baseline drusen area and volume, which was 4.69mm2 and 0.21mm3 in average for group A and 1.78mm2 resp. 0.07mm3 for group B.
Drusen show a steady increase of area and volume over time, which can be measured precisely using PS-OCT. Interestingly, the progression rates were roughly linear and patients could be classified into a "fast progression group" and a "low progression group". Further studies will show the prognostic value of this classification. The exact measurements made by PS-OCT outranges any other drusen detection algorithm and enables future clinical studies investigating the influence of prophylactic treatments on the progression of early AMD.
This PDF is available to Subscribers Only