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Sruthi Arepalli, Marco Pellegrini, Carol Shields; EDI-OCT Findings in Unilateral Choroidal Melanocytosis with Macular Involvement. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4232.
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To assess retinal and choroidal features in eyes with unilateral choroidal melanocytosis using enhanced depth imaging optical coherence tomography (EDI-OCT).
Retrospective case series with review of chart, fundus photography and EDI-OCT images. Included patients had unilateral choroidal melanocytosis with macular involvement (sectoral or complete) evaluated by EDI-OCT (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg, Germany). For each patient retinal and choroidal layers were assessed. Mean subfoveal choroidal thickness was manually determined independently by 2 physicians (SA and MP) using the caliper function on a cross-line scan passing through the foveola (averaging equal 100 frames) from inner choroidal limit to sclero-choroidal junction. Choroidal thickness of study fovea was then compared with the unaffected opposite (control) fovea.
Of 13 patients enrolled in the study (9 males,4 females), the mean age was 26 years (range 5-76 years). The choroidal melanocytosis was diffuse in 4 and sectoral in 9. Associated features included dermal (4), scleral (9) iris (1) and palate (2) melanocytosis. Spectral domain EDI-OCT showed normal inner retina (n=13) and normal outer retina (n=11). The affected choroid showed smooth surface contour without nodularity (n=13), dense shadowing (n=13), and compression of vascular tissue inward (n=12). The mean choroidal thickness was 317.2 in the study eye and 263.1 in the control eye. (p=0,23). The subfoveal choroidal thickness was 21% greater in the eye with melanocytosis compared with control.
EDI-OCT revealed eyes with choroidal melanocytosis show 21% thicker subfoveal region compared to opposite unaffected eye. Overlying retinal features were generally preserved.
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