June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
EDI-OCT Findings in Unilateral Choroidal Melanocytosis with Macular Involvement
Author Affiliations & Notes
  • Sruthi Arepalli
    Ocular Oncology, Wills Eye Institute, Philadelphia, PA
  • Marco Pellegrini
    Ocular Oncology, Wills Eye Institute, Philadelphia, PA
  • Carol Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, PA
  • Footnotes
    Commercial Relationships Sruthi Arepalli, None; Marco Pellegrini, None; Carol Shields, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4232. doi:
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      Sruthi Arepalli, Marco Pellegrini, Carol Shields; EDI-OCT Findings in Unilateral Choroidal Melanocytosis with Macular Involvement. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4232.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To assess retinal and choroidal features in eyes with unilateral choroidal melanocytosis using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: Retrospective case series with review of chart, fundus photography and EDI-OCT images. Included patients had unilateral choroidal melanocytosis with macular involvement (sectoral or complete) evaluated by EDI-OCT (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg, Germany). For each patient retinal and choroidal layers were assessed. Mean subfoveal choroidal thickness was manually determined independently by 2 physicians (SA and MP) using the caliper function on a cross-line scan passing through the foveola (averaging equal 100 frames) from inner choroidal limit to sclero-choroidal junction. Choroidal thickness of study fovea was then compared with the unaffected opposite (control) fovea.

Results: Of 13 patients enrolled in the study (9 males,4 females), the mean age was 26 years (range 5-76 years). The choroidal melanocytosis was diffuse in 4 and sectoral in 9. Associated features included dermal (4), scleral (9) iris (1) and palate (2) melanocytosis. Spectral domain EDI-OCT showed normal inner retina (n=13) and normal outer retina (n=11). The affected choroid showed smooth surface contour without nodularity (n=13), dense shadowing (n=13), and compression of vascular tissue inward (n=12). The mean choroidal thickness was 317.2 in the study eye and 263.1 in the control eye. (p=0,23). The subfoveal choroidal thickness was 21% greater in the eye with melanocytosis compared with control.

Conclusions: EDI-OCT revealed eyes with choroidal melanocytosis show 21% thicker subfoveal region compared to opposite unaffected eye. Overlying retinal features were generally preserved.

Keywords: 744 tumors • 550 imaging/image analysis: clinical  

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