Abstract
Purpose:
To assess retinal and choroidal features in eyes with unilateral choroidal melanocytosis using enhanced depth imaging optical coherence tomography (EDI-OCT).
Methods:
Retrospective case series with review of chart, fundus photography and EDI-OCT images. Included patients had unilateral choroidal melanocytosis with macular involvement (sectoral or complete) evaluated by EDI-OCT (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg, Germany). For each patient retinal and choroidal layers were assessed. Mean subfoveal choroidal thickness was manually determined independently by 2 physicians (SA and MP) using the caliper function on a cross-line scan passing through the foveola (averaging equal 100 frames) from inner choroidal limit to sclero-choroidal junction. Choroidal thickness of study fovea was then compared with the unaffected opposite (control) fovea.
Results:
Of 13 patients enrolled in the study (9 males,4 females), the mean age was 26 years (range 5-76 years). The choroidal melanocytosis was diffuse in 4 and sectoral in 9. Associated features included dermal (4), scleral (9) iris (1) and palate (2) melanocytosis. Spectral domain EDI-OCT showed normal inner retina (n=13) and normal outer retina (n=11). The affected choroid showed smooth surface contour without nodularity (n=13), dense shadowing (n=13), and compression of vascular tissue inward (n=12). The mean choroidal thickness was 317.2 in the study eye and 263.1 in the control eye. (p=0,23). The subfoveal choroidal thickness was 21% greater in the eye with melanocytosis compared with control.
Conclusions:
EDI-OCT revealed eyes with choroidal melanocytosis show 21% thicker subfoveal region compared to opposite unaffected eye. Overlying retinal features were generally preserved.
Keywords: 744 tumors •
550 imaging/image analysis: clinical