June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
The Effect Of Age On The Lens Ultrastructure During Accommodation As Measured Using Slit Lamp Photos And Wave Front Analysis
Author Affiliations & Notes
  • Rebecca Zoltoski
    Illinois College of Optometry, Chicago, IL
  • Elizabeth Wyles
    Illinois College of Optometry, Chicago, IL
  • Jennifer Harthan
    Illinois College of Optometry, Chicago, IL
  • Jer Kuszak
    LensAR, Orlando, FL
  • Footnotes
    Commercial Relationships Rebecca Zoltoski, None; Elizabeth Wyles, None; Jennifer Harthan, None; Jer Kuszak, LensAR, Inc. (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4264. doi:
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      Rebecca Zoltoski, Elizabeth Wyles, Jennifer Harthan, Jer Kuszak; The Effect Of Age On The Lens Ultrastructure During Accommodation As Measured Using Slit Lamp Photos And Wave Front Analysis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4264.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: During dynamic focusing, the shape, as well as the ultra-structure of the lens is changed. We have hypothesized that unique structural features and organization of fiber cells enables them to interface at the sutures resulting in a change in surface curvature of the lens, as well as an increase in thickness, allowing near focus to occur. We are reporting extended data on lens slit lamp photos, OCT of lens thickness changes, and sequential ray tracing analysis of the patterns associated with the lens sutures to provide additional insight into the importance of the ultra-structure of the lens in the accommodative process.

Methods: OCT (Visante™), wavefront analysis (iTrace™), and slit lamp photos (Haag Streit, 16X magnification, dilated eye) were collected on the right eye of normal subjects, between the ages of 7 - 63 (n=30). Accommodation was stimulated using minus lenses in front of the viewing eye in 2.5 D increments until the subject could no longer clearly view the target. For the photos a prism system was used to keep the eye appropriately oriented. The objective accommodative response was calculated as the change from a distance measurement refractive value. ImageJ (NIH) was used to analyze the area of the sutural components. Data were analyzed using Systat v11 to correlate accommodative response (AR) with total HOA, SA and the foil patterns, as well as changes in slit lamp suture areas. Spearman Rank Correlation coefficients and p values are presented.

Results: Lens thickness increases by 0.13 ± 0.05 μm/D during accommodation. The total foil aberration pattern was correlated with AR (r2=0.5, p=0.04). There was a decrease in suture band thickness that correlated with the AR (r2=-0.5, p<0.001).

Conclusions: Regardless of age, increase in accommodative response results in changes in the ultra-structure of the lens, as evidenced by the decrease in area of the dark central region of the suture and in the total foil patterns. Further analysis of these changes will provide further insight into the anatomical basis of accommodation.

Keywords: 404 accommodation • 419 anatomy  

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