Purchase this article with an account.
shah nawaz, Prafulla Maharana, Namrata Sharma, Rasik Vajpayee; To evaluate the efficacy of corneal collagen crosslinking in fungal corneal ulcers. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4304.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To study the efficacy of corneal collagen crosslinking(CXL) in treatment of moderate fungal corneal ulcers.
Thirty-seven cases of micro-biologically proven moderate fungal corneal ulcers were divided in two groups.Group 1 received medical therapy with CXL on day 1 of presentation. Group 2 received medical therapy alone.Medical therapy included topical Natamycin 5% drops .In cases of deep and large ulcers additional systemic therapy was given. CXL was done using riboflavin 1% with UVA 370nm. The parameters analyzed included healing time, final BCVA and perforation rate.
Mean age in group 1 was 43.5 ±17.01 years and 39.6±19.7 years in group 2, statistically insignificant(p value 0.604). Average ulcer size in-group 1 was 25.79±16.7 mm2 and 25.4±12.4 mm2 in-group 2, statistically insignificant (p value 0.915). BCVA at presentation in group 1 was 1.48 ±0.46 Log MAR and 1.56±0.435 Log MAR in group 2, statistically insignificant (p value 0.6618). 13 out of 15 cases (86.6%) in group 1 and 11/12 (91.67%) cases in group 2 healed (p value 0.56), statistically not significant .The average healing time of ulcer in group 1 was 43.08 days ±26.6 and 39.2± 19.7 days in group 2, statistically insignificant (p value 0.673). Final BCVA in group 1 was 1.3522 ±0.46 Log MAR and 1.26± 0.43 Log MAR in group 2, statistically insignificant (p value 0.434).
CXL offers no advantage as an adjunctive treatment in the treatment of moderate fungal corneal ulcers.
This PDF is available to Subscribers Only