June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Improvement of post-cataract dry eye by 0.05% cyanocobalamine plus 0.5% taurine and 0.5% long-chained hyaluronic acid
Author Affiliations & Notes
  • Federico Solignani
    Ophthalmology Dept - Ocular surface disease research center, University of Genoa, Genoa, Italy
  • Monica Zurria
    Medical Dept, Alfa Intes Ind Ter Spl srl, Casoria, Italy
  • Maurizio Rolando
    Ophthalmology Dept - Ocular surface disease research center, University of Genoa, Genoa, Italy
    Is.Pre Oftalmica, Genoa, Italy
  • Footnotes
    Commercial Relationships Federico Solignani, None; Monica Zurria, Alfa Intes Ind Ter Spl srl (E); Maurizio Rolando, Bausch & Lomb (F), Allergan (R), Alcon (R), Santen (R), Merck (R), Thea (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4305. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Federico Solignani, Monica Zurria, Maurizio Rolando; Improvement of post-cataract dry eye by 0.05% cyanocobalamine plus 0.5% taurine and 0.5% long-chained hyaluronic acid. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4305. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To study the effects of 0.05% cyanocobalamine in combination with 0.5% taurine and 0.5% long-chained hyaluronic acid (IALUVIT® ophthalmic solution, Alfa Intes, Italy) and its impact on functional recovery related to patient comfort, in post-cataract dry eye (PCDE).

Methods: Records from 20 patients (mean age 75.35+7.07 years, 8 males and 12 females) undergone phacoemulsification (sutureless, temporal incision) were selected. In addition to routine post-operative protocol, 10 patients had received IALUVIT® for 3 months; 10 patients were considered as control. Break-up time (BUT), conjunctival and corneal staining, temporal, central and nasal corneal sensitivity (Cochet-Bonnet aesthesiometer), were considered before surgery and 1, 7, 30 and 90 days after surgery. Frequency and extent of symptoms (foreign body sensation, stinging, burning, discomfort at blinking) had been registered using a VARS before and 7, 30 and 90 days after surgery.

Results: BUT, staining scores, and corneal sensitivity were affected by surgery in all patients. BUT increased during the follow-up and it was significantly better in treated patients than controls at day 30 and 90 (respectively, 13.3+0.94 vs 10.8+1.31 at day30 and 13.7+1.05 vs 11.1+1.52 at day90, p<0.0001). Staining scores recovered within 1 month in both groups, with a statistically significant effect of the treatment both at day30 and day90 (p<0.0001). Corneal sensitivity returned to baseline levels in all patients at day90, however the time course in treated eyes was significantly different within each measurement (p<0.0001). Foreign body sensation, stinging and discomfort at blinking were significantly different in treated patients, both as frequency and extent of symptom perception (p<0.0001). No significant change in burning was observed. Finally, there was a strong correlation between symptoms and corneal sensitivity values, at each considered point.

Conclusions: Despite successful surgery, patients always complain of PCDE related to different causes, including the disruption of normal cornea nerves and sensitivity. The present data show that adding to post-surgery therapy an ophthalmic solution whose ingredients (especially cyanocobalamine and taurine) have an impact on nerves could improve cornea health thus reducing patient dissatisfaction, when the adjunctive therapy is extended from 1 to 3 months after surgery.

Keywords: 486 cornea: tears/tear film/dry eye • 445 cataract • 729 taurine  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×