June 2013
Volume 54, Issue 15
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ARVO Annual Meeting Abstract  |   June 2013
Retinal Oximetry with Scanning Laser Ophthalmoscope
Jona Kristjansdottir; Sveinn Hardarson; Gisli Halldorsson; Robert Karlsson; Thorunn Eliasdottir; Einar Stefánsson
Author Affiliations & Notes
  • Jona Kristjansdottir
    Ophthalmology, Landspitali, University Hospital, Reykjavik, Iceland
    University of Iceland, Reykjavik, Iceland
  • Sveinn Hardarson
    Ophthalmology, Landspitali, University Hospital, Reykjavik, Iceland
    University of Iceland, Reykjavik, Iceland
  • Gisli Halldorsson
    Oxymap ehf., Reykjavik, Iceland
  • Robert Karlsson
    Oxymap ehf., Reykjavik, Iceland
  • Thorunn Eliasdottir
    Ophthalmology, Landspitali, University Hospital, Reykjavik, Iceland
    University of Iceland, Reykjavik, Iceland
  • Einar Stefánsson
    Ophthalmology, Landspitali, University Hospital, Reykjavik, Iceland
    University of Iceland, Reykjavik, Iceland
  • Footnotes
    Commercial Relationships Jona Kristjansdottir, Optos plc. (F); Sveinn Hardarson, Oxymap ehf. (F), Oxymap ehf. (I), Oxymap ehf. (C), Oxymap ehf. (R), Patent no. 7774036 (P), Patent application 13/377,749 (P), Optos plc. (F); Gisli Halldorsson, Oxymap ehf (E), Oxymap ehf (I); Robert Karlsson, Oxymap ehf. (E), Oxymap ehf. (P), Oxymap ehf. (I); Thorunn Eliasdottir, None; Einar Stefánsson, Oxymap ehf (P), Oxymap ehf (I), Oculis ehf (P), Oculis ehf (I), Risk ehf (I), Acta Ophthalmologica (E)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 44. doi:
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      Jona Kristjansdottir, Sveinn Hardarson, Gisli Halldorsson, Robert Karlsson, Thorunn Eliasdottir, Einar Stefánsson; Retinal Oximetry with Scanning Laser Ophthalmoscope. Invest. Ophthalmol. Vis. Sci. 2013;54(15):44.

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Abstract
 
Purpose
 

To test the sensitivity of a scanning laser ophthalmoscope for measurements of hemoglobin oxygen saturation in retinal blood vessels.

 
Methods
 

Fundus images were acquired with a scanning laser ophthalmoscope, Optomap 200Tx (Optos plc.). The device uses two wavelengths for image acquisition, 532 and 633 nm. Images taken at both wavelengths were analyzed with the Oxymap Analyzer software (Oxymap ehf.), which automatically tracks retinal vessels and calculates optical density ratio (ODR) between wavelengths for the vessels. ODR is inversely related to oxygen saturation. Two different methods were used to investigate the sensitivity of the device, oxygen inhalation and measurements of patients with central retinal vein occlusion, where hypoxia has been confirmed with Oxymap T1 oximeter. Two healthy subjects were measured after inhalation of pure oxygen for 10 minutes (10L/min) and every 5 seconds for the next 135 seconds, during recovery. Three patients with central retinal vein occlusion (CRVO) and one patient with hemi-central retinal vein occlusion were measured.

 
Results
 

The figure shows results from the oxygen inhalation testing and the table shows oxygen saturation (mean±standard deviation) from CRVO patients, affected eye and fellow eye.

 
Conclusions
 

The Optomap 200Tx, scanning laser ophthalmoscope is sensitive to changes in oxygen saturation, but the variability between measurements is considerable as indicated by high standard deviation of saturation measurements. Further technical improvement is needed for optimization of measurements.

 
Figure. The figure shows oxygen saturation over time for arterioles and venules for two healthy subjects (A and B). Subjects inhaled pure oxygen for 10 minutes (10L/min) and fundus images were acquired with Optomap 200Tx after the inhalation ended (time=0) and every 5 seconds for 135 seconds during recovery time.
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Figure. The figure shows oxygen saturation over time for arterioles and venules for two healthy subjects (A and B). Subjects inhaled pure oxygen for 10 minutes (10L/min) and fundus images were acquired with Optomap 200Tx after the inhalation ended (time=0) and every 5 seconds for 135 seconds during recovery time.
 
Figure. The figure shows oxygen saturation over time for arterioles and venules for two healthy subjects (A and B). Subjects inhaled pure oxygen for 10 minutes (10L/min) and fundus images were acquired with Optomap 200Tx after the inhalation ended (time=0) and every 5 seconds for 135 seconds during recovery time.
Figure. The figure shows oxygen saturation over time for arterioles and venules for two healthy subjects (A and B). Subjects inhaled pure oxygen for 10 minutes (10L/min) and fundus images were acquired with Optomap 200Tx after the inhalation ended (time=0) and every 5 seconds for 135 seconds during recovery time.
View OriginalDownload Slide
 
Table. The table shows oxygen saturation (mean±standard deviation for each eye) for four patients with either central retinal vein occlusion or hemi-central retinal vein occlusion.
View OriginalDownload Slide
 
Table. The table shows oxygen saturation (mean±standard deviation for each eye) for four patients with either central retinal vein occlusion or hemi-central retinal vein occlusion.
 
Table. The table shows oxygen saturation (mean±standard deviation for each eye) for four patients with either central retinal vein occlusion or hemi-central retinal vein occlusion.
Table. The table shows oxygen saturation (mean±standard deviation for each eye) for four patients with either central retinal vein occlusion or hemi-central retinal vein occlusion.
View OriginalDownload Slide
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 635 oxygen • 688 retina  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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