June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Retinal and Macular Morphology is Correlated with Retrobulbar Vascular Resistance in Diabetic Patients with Glaucoma
Austin Gerber; Alon Harris; Brent Siesky; George Eckert; Ingrida Januleviciene; Nathaniel Kim; Annahita Amireskandari; Brian Marek; Leslie Tobe; Andrew Huck
Author Affiliations & Notes
  • Austin Gerber
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Alon Harris
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Brent Siesky
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • George Eckert
    Division of Biostatistics, Indiana Univ School of Med, Indianapolis, IN
  • Ingrida Januleviciene
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Nathaniel Kim
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Annahita Amireskandari
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Brian Marek
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Leslie Tobe
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Andrew Huck
    Ophthalmology, Indiana Univ School of Med, Indianapolis, IN
  • Footnotes
    Commercial Relationships Austin Gerber, None; Alon Harris, MSD (R), Alcon (R), Merck (C), Pharmalight (C), ONO (C), Sucampo (C), Adom (I); Brent Siesky, None; George Eckert, None; Ingrida Januleviciene, Pharmalight (F), Santen (C), Alcon (C), MSD (C); Nathaniel Kim, None; Annahita Amireskandari, None; Brian Marek, None; Leslie Tobe, None; Andrew Huck, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4447. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Retinal and Macular Morphology is Correlated with Retrobulbar Vascular Resistance in Diabetic Patients with Glaucoma
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Austin Gerber, Alon Harris, Brent Siesky, George Eckert, Ingrida Januleviciene, Nathaniel Kim, Annahita Amireskandari, Brian Marek, Leslie Tobe, Andrew Huck; Retinal and Macular Morphology is Correlated with Retrobulbar Vascular Resistance in Diabetic Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4447.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: To examine the relationship between changes in retinal and macular morphology and retrobulbar blood flow in diabetic and non-diabetic patients with open angle glaucoma (OAG) after three years.

Methods: 68 patients (15 diabetic, 53 non-diabetic) with OAG were assessed for retinal nerve fiber layer (RNFL) thickness and macular morphology using optical coherence tomography (OCT) and retrobulbar blood flow in the ophthalmic artery (OA), central retinal artery (CRA) and nasal (NPCA) and temporal (TPCA) posterior ciliary arteries using color Doppler imaging (CDI) at baseline and three years follow up. Pearson correlations were calculated to evaluate the associations between measurements at baseline and between the changes in measurements between baseline and 3 years.

Results: In OAG patients with diabetes, change in OA resistive index (RI) was strongly and negatively correlated with change in average RNFL thickness (r=-0.93, p=0.02), inner superior macular thickness (r=-0.85, p=0.03), outer inferior macular thickness (r=-0.97, p=0.03), inner nasal macular thickness (r=-0.85, p=0.03), outer temporal macular thickness (r=-0.95, p<0.01) and macular volume (r=-0.90, p=0.01) and change in NPCA RI was strongly and negatively correlated with change in temporal RNFL thickness (r=-0.90, p=0.04), inner nasal macular thickness (r=-0.84, p=0.03), inner temporal macular thickness (r=-0.84, p=0.03) and macular volume (r=-0.83, p=0.04) with statistical significance over three years. In OAG patients without diabetes, these correlations were weak and did not reach statistical significance (r=-0.32 to 0.02, p>0.05). There was a statistically significant difference in strength of correlations between groups for each relationship (p<0.01). In diabetic patients, change in CRA EDV was correlated with change in superior and inferior RNFL thickness (r=-0.89, p=0.05; r=-0.72, p=0.19). Other correlations between CRA and NPCA PSV and EDV were weak (r=-0.57 to 0.33) in both diabetics and non-diabetics and only statistically significant in non-diabetics (diabetics p>0.05, non-diabetics p<0.01).

Conclusions: Changes in vascular resistance were strongly correlated with deterioration of the RNFL and macula in OAG patients with diabetes. This suggests that diabetics may have a stronger vascular component to their glaucomatous progression than non-diabetics.

Keywords: 498 diabetes • 585 macula/fovea • 436 blood supply  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept