June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Optic Nerve Head Morphology and Retrobulbar Blood Flow; Differences between Glaucoma Patients with and without Diabetes
Joshua Paschall; Alon Harris; Brent Siesky; Leslie Tobe; Annahita Amireskandari; Nathaniel Kim; Chi-Wah Yung; Brian Marek; Darrell WuDunn; John Abrams
Author Affiliations & Notes
  • Joshua Paschall
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Brent Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Leslie Tobe
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Annahita Amireskandari
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Nathaniel Kim
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Chi-Wah Yung
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Brian Marek
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • John Abrams
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Footnotes
    Commercial Relationships Joshua Paschall, None; Alon Harris, MSD (R), Alcon (R), Merck (C), Pharmalight (C), ONO (C), Sucampo (C), Adom (I); Brent Siesky, None; Leslie Tobe, None; Annahita Amireskandari, None; Nathaniel Kim, None; Chi-Wah Yung, None; Brian Marek, None; Darrell WuDunn, Merck (R), Alcon (R); John Abrams, ADOM (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4467. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Optic Nerve Head Morphology and Retrobulbar Blood Flow; Differences between Glaucoma Patients with and without Diabetes
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Joshua Paschall, Alon Harris, Brent Siesky, Leslie Tobe, Annahita Amireskandari, Nathaniel Kim, Chi-Wah Yung, Brian Marek, Darrell WuDunn, John Abrams; Optic Nerve Head Morphology and Retrobulbar Blood Flow; Differences between Glaucoma Patients with and without Diabetes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4467.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: To evaluate retrobulbar blood flow in relation to optic nerve head (ONH) morphology over time in open-angle glaucoma (OAG) patients with and without diabetes.

Methods: 77 patients (17 diabetic, 60 non-diabetic) with OAG were assessed for ONH morphology utilizing Heidelberg retinal tomography and optical coherence tomography (cup/disc (C/D) ratio, cup shape, cup depth, disc area, rim area, rim width, rim volume, height variation contour). Retrobulbar blood flow was measured using Color Doppler imaging (CDI) in the ophthalmic artery (OA), central retinal artery (CRA) and nasal (NPCA) and temporal (TPCA) posterior ciliary arteries. Pearson correlations were calculated to evaluate the associations between measurements at baseline and between the changes in measurements between baseline and 3 years.

Results: Changes in OA peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) in OAG patients with diabetes strongly correlated (r=-0.95 to 0.78) with changes in multiple ONH parameters, and were significantly different compared to OAG patients without diabetes (p<0.0043). Changes in CRA PSV and EDV were more strongly correlated in diabetics with ONH changes than non-diabetics (r=-0.78 to -0.56: r=0.43 to 0.31; p<0.0023). Changes in NPCA EDV were strongly and significantly correlated (r=-0.87 to -0.59; p=0.02 to 0.25) with ONH changes in diabetics and weakly correlated in non-diabetics (r=0.34 to 0.18) with significant differences between groups (p<0.002). NPCA RI changes strongly correlated with ONH changes in diabetics (r=-0.91 to -0.72), and weakly correlated in non-diabetics (r=0.35 to -0.14) with significant differences between groups (p<0.001).

Conclusions: In this cohort of OAG patients, changes in ONH morphology were strongly correlated to retrobulbar blood flow changes in diabetics. This data indicates that changes in ONH morphology may be more influenced by ocular blood flow in for OAG patients with diabetes.

Keywords: 498 diabetes • 436 blood supply  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept