June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Dynamic retinal venous oscillations are changed in diabetes mellitus type 1
Author Affiliations & Notes
  • Konstantin Kotliar
    Biomedical Engineering, Aachen University of Applied Sciences, Juelich, Germany
    Ophthalmology, Munich University of Technology, Munich, Germany
  • Ines Lanzl
    Ophthalmology, Munich University of Technology, Munich, Germany
  • Thorsten Siegmund
    Endocrinology and Diabetes, Bogenhausen Hospital, Munich, Germany
  • Arno Schmidt-Trucksaess
    Preventive Sports Medicine, Munich University of Technology, Munich, Germany
    Division of Sports Medicine, University of Basel, Basel, Switzerland
  • Footnotes
    Commercial Relationships Konstantin Kotliar, None; Ines Lanzl, allergan (C), alcon (R), pfizer (R), santen (R), novartis (R); Thorsten Siegmund, None; Arno Schmidt-Trucksaess, None
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4631. doi:https://doi.org/
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      Konstantin Kotliar, Ines Lanzl, Thorsten Siegmund, Arno Schmidt-Trucksaess; Dynamic retinal venous oscillations are changed in diabetes mellitus type 1. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4631. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: We demonstrated previously that non-stimulated temporal retinal arterial and venous oscillations (pulsations and vasomotions) are changed in healthy volunteers with age and in patients with primary open angle glaucoma. Whether this dynamic retinal vessel behavior is altered in diabetes mellitus type 1 (DM1) is investigated.

Methods: 33 untreated patients with DM1 (age 51.7±8.3 years) with no or non-proliferative retinopathy and 33 age and sex matched medically healthy volunteers were examined by Dynamic Vessel Analyzer (DVA, IMEDOS, Jena, Germany). Temporal changes of vessel diameters of retinal arterial and venous vessel segments were examined with DVA in all subjects during 40 seconds. Oscillatory temporal changes of vessel diameter were divided into high-frequent (period < 1,5 s) and low-frequent (period ≥ 1,5 s) and were evaluated using methods of mathematical signal analysis.

Results: Quantitative parameters characterizing dynamic retinal vessel behavior did not show any differences in retinal arterial oscillations between DM1 patients and healthy control subjects. In veins there was a significant difference in the rate of periodicity of high-frequency (control: 0.08(0.06; 0.17), DM1: 0.12(0.08; 0.23) [median (1.quartile; 3. quartile)], p < 0.05) as well as of low-frequency oscillations (control: 0.16(0.10; 0.24), DM1: 0.62(0.49; 1.23), p < 0.001) between the groups.

Conclusions: Functional and morphological alterations in the retinal veins in DM1 with no or mild non-proliferative retinopathy are shown using a non-invasive in-vivo methodology. Changed retinal venous behavior in the initial stages of diabetes mellitus might be an indication for alterations in the vascular endothelium and blood flow regulation in this disease.

Keywords: 498 diabetes • 550 imaging/image analysis: clinical • 688 retina  
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