June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Ocular rigidity as estimated based on measurement of pulse amplitude using pneumotonometry and fundus pulse is dependent on intraocular pressure
Author Affiliations & Notes
  • Anton Hommer
    Krankenhaus Hera Vienna, Vienna, Austria
    Dep.of. Clinical Pharmacology, University Clinic, Vienna, Austria
  • Gerhard Garhofer
    Dep.of. Clinical Pharmacology, University Clinic, Vienna, Austria
  • Leopold Schmetterer
    Dep.of. Clinical Pharmacology, University Clinic, Vienna, Austria
  • Footnotes
    Commercial Relationships Anton Hommer, Allergan (R), Allergan (C), Alcon (R), Santen (R), Merck (R); Gerhard Garhofer, None; Leopold Schmetterer, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4671. doi:
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      Anton Hommer, Gerhard Garhofer, Leopold Schmetterer; Ocular rigidity as estimated based on measurement of pulse amplitude using pneumotonometry and fundus pulse is dependent on intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4671.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Evidence has accumulated that the biomechanical properties of the optic nerve head and the sclera play a role in the pathophysiology of glaucoma. In this study, the hypothesis was tested that abnormal ocular structural stiffness as estimated based on measurements of intraocular pressure amplitude and ocular fundus pulsation amplitude is dependent on intraocular pressure.

Methods: Onehundredsixtyeight healthy subjects aged between 18 and 45 years were included in this study. The ocular pulse amplitude and pulsatile ocular blood flow were assessed with pneumotonometry. The fundus pulsation amplitude was measured by using laser interferometry. Based on the Friedenwald equation, a coefficient of ocular rigidity (E1) was calculated relating pulse amplitude to fundus pulsation amplitude

Results: The ocular fundus pulsation amplitude was 4.21 ± 0.99 μm, the ocular pulse amplitude was 3.07 ± 0.61 mmHg. This resulted in a calculated factor E1 of 0.047 ± 0.007 AU. Multiple regression analysis revealed that fundus pulsation amplitude and pulse amplitude were dependent on pulse pressure amplitude (p < 0.001) whereas E1 was dependent on intraocular pressure (p < 0.001).

Conclusions: The present study indicates that ocular rigidity is dependent on intraocular pressure.

Keywords: 568 intraocular pressure  
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