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Eung Kweon Kim, Tyler Hyung Taek Rim, Hong Seok Kim, Tae-im Kim; The degree of exacerbated interfacial opacity after LASIK in Granular Corneal Dystrophy type 2 is related with the width of area of granular deposits made before procedure. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4741.
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To find out the relationship between the degree of exacerbated interfacial opacity after laser in situ keratomileusis (LASIK) and typical granular or linear deposit areas in Granular Corneal Dystrophy type 2 (GCD2).
We retrospectively reviewed the records and slit-lamp photographs of 119 patients with GCD2 who underwent LASIK. All patients received LASIK once before and were diagnosed as being heterozygous for GCD2 by DNA analysis from peripheral blood later. We evaluated the area of each type of lesions using inForm® (Perkin Elmer, Inc, Waltham, MA). We designed grades as 5 steps based on the density and width of the area of interfacial opacities. We investigated the areas of granular and linear lesions as potential factors associated with grade.
Granular lesion was located in sub-Bowman’s layer level, and linear lesion was located in deep stromal level. These lesions were considered as pre-opacified lesions before LASIK. The visual acuity gradually decreased as the grade of interfacial opacity increased (p<0.01). The grade of the interfacial opacity was related positively with the width of the area of granular lesion (p<0.01). In multivariate analysis, the group having larger area of granule was more likely to have severe interfacial opacity comparing to smaller area of granule (adjusted OR=8.1, p<0.01), and the group with linear lesion was more likely to have severe interfacial opacity comparing to those without linear lesion (adjusted OR=6.6, p=0.02).
Our data suggest that pre-opacified area, especially the area of granular lesion, is a significant factor for the severity of exacerbation after LASIK. The disability of cleaning up of the deposit material before LASIK would result in heavy deposits along the interface after LASIK.
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