June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Ultrasonic Circular Cyclo Coagulation in patients with Primary Open-Angle Glaucoma: a Multicenter Clinical Trial
Author Affiliations & Notes
  • Florent Aptel
    Grenoble University Hospital, Grenoble, France
  • Philippe Denis
    Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
  • Jean-Francois Rouland
    Hôpital Claude Huriez, CHRU de Lille, Lille, France
  • Jean-Philippe Nordmann
    Centre Hospitalier National des Quinze-Vingts, Paris, France
  • Yves Lachkar
    Institut du glaucome, Fondation Hôpital Saint-Joseph, Paris, France
  • Jean-Paul Renard
    Hôpital d'Instruction des Armées du Val de Grâce, Paris, France
  • Eric Sellem
    Centre Ophtalmologique Kléber, Lyon, France
  • Christophe Baudouin
    Centre Hospitalier National des Quinze-Vingts, Paris, France
  • Alain Bron
    Dijon University Hospital, Dijon, France
  • Footnotes
    Commercial Relationships Florent Aptel, EyeTechCare (C); Philippe Denis, Eyetechcare (C), Alcon (C), Thea (C), Allergan (C), MSD (C); Jean-Francois Rouland, Thea (R), Eyetechcare (R); Jean-Philippe Nordmann, None; Yves Lachkar, None; Jean-Paul Renard, None; Eric Sellem, ALCON (C), ALLERGAN (C), MSD (C), THÉA (C), EYETECHCARE (C); Christophe Baudouin, None; Alain Bron, Allergan (C), Bausch Lomb (C), Horus (F), Théa (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4775. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Florent Aptel, Philippe Denis, Jean-Francois Rouland, Jean-Philippe Nordmann, Yves Lachkar, Jean-Paul Renard, Eric Sellem, Christophe Baudouin, Alain Bron; Ultrasonic Circular Cyclo Coagulation in patients with Primary Open-Angle Glaucoma: a Multicenter Clinical Trial. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4775.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure.

Methods: Prospective non comparative interventional clinical study performed in 9 French glaucoma centers. Forty-two eyes of 42 patients with primary open-angle glaucoma (POAG), intraocular pressure (IOP) > 21 mmHg, an average of 1.65 failed previous surgeries and an average of 3.2 hypotensive medications were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated, 18 patients (group 1) were treated with a 4 seconds exposure time for each shot and 24 patients (group 2) with a 6 seconds exposure time. Complete ophthalmic examinations were performed before the procedure, and at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Primary outcomes were surgical success (defined as IOP reduction from baseline ≥ 20% and IOP > 5mmHg) at the last follow-up visit, and vision-threatening complications. Secondary outcomes were mean IOP at each follow-up visits compared to baseline, medication use, complications, and re-interventions.

Results: IOP was significantly reduced in both groups (p<0.05), from a mean preoperative value of 28.6 ± 4.7 mmHg in group 1 and 28.1 ± 8.6 mmHg in group 2 to a mean value of 16.1 ± 2.8 mmHg in group 1 and 16.7 ± 4.4 mmHg in group 2 at last follow-up. Success (IOP reduction >20%) was achieved in 12 of 18 (67%) eyes of the group 1 and in 17 of 24 (71%) eyes of the group 2 at last follow-up. Four patients were ret-treated. No major intra- or post-operative complications occurred.

Conclusions: Ultrasonic Circular Cyclo Coagulation seems to be an effective and well-tolerated method to reduce intraocular pressure in patients with POAG.

Keywords: 455 ciliary body • 568 intraocular pressure  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.