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David Reed, Jesse Gilbert, Sayoko Moroi; Association of Aqueous Humor Dynamic Markers in Glaucoma With Canaloplasty Surgery. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4787.
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© ARVO (1962-2015); The Authors (2016-present)
This retrospective case series was designed to examine markers that may be predictive of canaloplasty outcomes. We hypothesize that the potential markers include: fluorescein diffusion into the anterior chamber, blood reflux in the anterior chamber, and episcleral venous drainage.
This study is a retrospective case series of 16 consecutive patients, who underwent canaloplasty surgery by a single surgeon. These patients were enrolled in an IRBMED approved protocol to review medical records for clinical research. During the process of the surgical technique, the surgeon incorporated fluorescein canalography as part of the canaloplasty procedure to evaluate these potential markers. High definition video was recorded on the majority of cases. The fluorescein diffusion, blood reflux, and fluorescein outflow pattern are being analyzed. These dynamic data will be correlated with the short-term canaloplasty results.
There were 4 females and 12 males, with a mean age and SD of 60 +/-19 years. The pre-operative mean maximum lOP within three clinic visits prior to surgery was 21 +/- 8.6 mmHg (range 12 - 45 mmHg). The glaucoma diagnoses included: juvenile glaucoma and open-angle forms of glaucoma. The final post-op lOP was 11 +/- 3.4 mmHg (range 2 - 15.5 mmHg). The functional evaluation of fluorescein diffusion, blood reflux, and fluorescein outflow will be demonstrated. These functional markers will be quantified and tested for association with the short-term canaloplasty results.
As suggested by Grieshaber et al (IOVS 51:498-504, 2010), functional evaluation of aqueous humor dynamic outflow may be helpful in assessing surgical outcome of canaloplasty.
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