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Maarten Huijbregtse, Dirk De Brouwere, Michiel Mensink; Glaucoma Assessment using Retinal Topography by Scanning Laser Ophthalmoscope Imaging. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4847.
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A 3D topographic reconstruction of the retinal surface can be a helpful aid in diagnosing and monitoring the occurrence and progression of retinal pathologies like glaucoma. In this study, we used a compact confocal Scanning Laser Ophthalmoscope (cSLO) to assess the presence of glaucoma in a mixed group of subjects through retinal topography of the optic nerve head.
For this study, a zero-dilation compact cSLO (EasyScan, i-Optics, The Netherlands) was modified to acquire stacks of retinal images at different focal depths. The confocal nature of the camera enables the 3D reconstruction of the retinal surface from a depth-resolved image stack after image registration. Besides ten healthy eyes, ten glaucomatous eyes were recruited. Subjects were excluded from the study when the optical media were unclear. The 45 degree nasal field was imaged twice for all eyes. Reconstructed topographic maps were rendered and presented to two experienced glaucoma graders.
Both graders referred the glaucomatous eyes with a strong agreement to the diagnosis as communicated in each patient’s medical record. Sensitivity and specificity were in line with the outcomes known in the standard practice for glaucoma diagnosis. Additionally, no significant difference could be observed when comparing the two different topographic reconstructions taken in each eye.
The results indicate that retinal topography can be implemented in a compact cSLO camera, in a precise enough manner to use it for diagnosing and monitoring glaucoma. We believe this will allow healthcare providers to prevent progression of visual loss in glaucomatous patients with treatments in the early stages of the pathology.
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