June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
In Vivo Dimensions of Schlemm’s Canal and Number of Collector Channels in the Nasal and Temporal Areas of Normal Eyes
Author Affiliations & Notes
  • Wendy Kirkland
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Sung Chul Park
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    Department of Ophthalmology, Valhalla, NY
  • Rafael Furlanetto
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Camila Netto
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Yiyi Liu
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    New York Medical College, Valhalla, NY
  • Jeffrey Liebmann
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Robert Ritch
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    Department of Ophthalmology, Valhalla, NY
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4850. doi:
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      Wendy Kirkland, Sung Chul Park, Rafael Furlanetto, Camila Netto, Yiyi Liu, Jeffrey Liebmann, Robert Ritch; In Vivo Dimensions of Schlemm’s Canal and Number of Collector Channels in the Nasal and Temporal Areas of Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4850.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine if differences exist in the dimensions of Schlemm’s canal (SC) and the number of collector channels (CCs) between the nasal and temporal areas of normal eyes using in vivo enhanced depth imaging optical coherence tomography (EDI OCT).

 
Methods
 

Serial horizontal EDI OCT B-scans were obtained in the nasal and temporal limbal areas from one eye of each normal subjects (81 scans per 15x5 degree rectangle; interval between scans, ~35 µm; Fig A and B). The cross-sectional area of SC was measured in each EDI OCT B-scan (Fig C). After three-dimensional SC reconstruction, SC volume was calculated for the nasal and temporal areas. The CCs connected to the SC (Fig D) were counted in these areas. SC measurements and CC counting were performed by an independent observer, who was masked to the clinical information of the examined eyes.

 
Results
 

Eleven normal eyes (11 subjects; mean age, 28±5 years) were included. The cross-sectional area of SC varied considerably within (mean of coefficients of variation of all eyes = 36%) and among the eyes (coefficient of variation of means of all eyes = 35%) (Fig E). The mean cross-sectional SC area was significantly greater nasally than temporally (3837±1397 µm2 vs. 3188±1204 µm2; p=0.034; Fig F), as was the SC volume (0.011±0.004 mm3 vs. 0.009±0.003 mm3; p=0.034). The SC cross-sectional area and volume were greater temporally than nasally in only one eye. The number of the CCs was significantly greater nasally than temporally (7.5±1.7 vs. 5.5±2.0; p=0.004; Fig G).

 
Conclusions
 

SC is larger with more CCs nasally than temporally in normal eyes. This may have important implications for the development of treatments that target the trabecular outflow pathway.

 
 
(A) 15x5 degree rectangle for 81 serial horizontal EDI OCT B-scans. (B) A horizontal EDI OCT B-scan of the limbus and sclera (red arrow = Schlemm’s canal [SC]). (C) SC was delineated (red dotted line) to measure its cross-sectional area. (D) Yellow arrows = collector channel. (E) Box-and-whisker plot for the SC cross-sectional area in 11 normal eyes (error bar = minimum and maximum values). (F and G) Mean SC area and the number of collector channels in 11 normal eyes.
 
(A) 15x5 degree rectangle for 81 serial horizontal EDI OCT B-scans. (B) A horizontal EDI OCT B-scan of the limbus and sclera (red arrow = Schlemm’s canal [SC]). (C) SC was delineated (red dotted line) to measure its cross-sectional area. (D) Yellow arrows = collector channel. (E) Box-and-whisker plot for the SC cross-sectional area in 11 normal eyes (error bar = minimum and maximum values). (F and G) Mean SC area and the number of collector channels in 11 normal eyes.
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 421 anterior segment • 419 anatomy  
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