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Nikolaus Feucht, Chris Lohmann, Patricia Kook, Christian Mayer, Miriam Zenk, Kerstin Wand, Mathias Maier; Differences in subfoveal choroidal thickness between acute and chronic central serous chorioretinopathy measured with enhanced depth imaging OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4857.
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The purpose of this study was to assess the subfoveal choroidal thickness in patients with central serous chorioretinopathia (CSC) with enhanced depth imaging OCT and to identify differences and characteristics in total choroidal thickness in subjects with chronic disease, acute disease and normal age matched controls
32 patients (mean age 46,3y) with central serous chorioretinopathy underwent enhanced depth imaging spectral-domain optical coherence tomography (HRA+OCT Spectrails® Heidelberg Engineering). The subfoveal choroidal thickness was assessed as the distance between Bruchs membrane/RPE complex and choroid/scleral junction. One horizontal scan with foveal fixation and of 6mm compromised of 100 averaged scans with activated EDI modus was used for analysis. Chronic disease was defined by subretinal fluid for more than 4 month and evidence of bilateral subretinal fluid was an exclusion criteria.
In subjects with chronic disease(n=23; mean age 46,6; mean duration of symptoms 42 weeks) the mean choroidal thickness was measured at 322,0µm (stdev.66,7, median 345µm). The fellow eye showed a thickness of 260,1µm (stdev.75,68, median 269µm). Patients with acute disease (n=9; mean age 40,3; mean duration of symptoms 7 weeks) the choroidal thickness was measured at a mean of 390,6µm (stdev. 31,12, median 394µm). The fellow eye showed a thickness of 301,3µm (stdev.65,6, median 339µm) 12 healthy subjects between 30 and 50years of age without any ocular disease were measured respectively and showed a subfoveal choroidal thickness of 275,9µm (stdev. 91,1) and 268.3µm (stdev. 77,2) In subjects with acute disease 66% and (69% in chronic)showed changes on the Bruch/RPE level with micro PED like lesions with hyperreflective content
Choroidal thickness was assessed thicker in patients with CSC than in healthy subjects of the same age group. In unilateral CSC the choroidal thickness was about 22,8% thicker in the affected eye than in the fellow eye. In cases with long standing disease this difference was 19,3% in healthy subjects only 2,5%. The data further confirms the finding that CSC is associated with a thickened choroidal thickness. The diference to healthy subjects was greater in acute cases with less than 4 month disease duration
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