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Tetsuju Sekiryu, Hiroshi Oyamada, Kimihiro Imaizumi, Takafumi Mori, Ichiro Maruko; Long-term changes of fudus autofluorescence in central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4916.
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© ARVO (1962-2015); The Authors (2016-present)
Hyperautofluorescence appears in the area of serous retinal detachment in central serous retinopathy (CSC). The constituents in the subretinal hyperautofluorescent materials may be different from that in the retinal pigment epithelium. We investigated that a long-term change of hyperautofluorescence that appeared in the subretinal space in the eyes with CSC.
Observational case series. Seventeen eyes of 17 patients were followed over 5 years after resolution of serous retinal detachment. All eyes showed hyperautofluorescence in the area of serous retinal detachment at the baseline. The eyes that showed recurrence of serous retinal detachment during the follow-up period were excluded. Fundus autofluorescence was taken with HRA2 (Heidelberg engineering). We measured the intensity of autofluorescence in the hyperautofluorescent area. The autofluorescence intensity was corrected by that in the unaffected area. Changes of the autofluorescence intensity during the follow-up period were calculated.
Hyperautofluorescence remained at the final visit in all eyes. The intensity of autofluorescence was -0.046 log unit at the first visit and -0.093 log unit at the final visit (P=0.0005). The intensity of hyperautofluorescence decreased 0.0009 log unit per year.
Hyperautofluorescence in the area of serous retinal detachment in CSC remains over 5 years, although the intensity of hyperautofluorescence decreases very slowly.
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