June 2013
Volume 54, Issue 15
Jump To...
Free
ARVO Annual Meeting Abstract  |   June 2013
Longitudinal Changes in Retinal Sensitivity among Patients with Maculopathy
Hongting Liu; Millena Bittencourt; Owhofasa Agbedia; Ahmadreza Moradi; Yasir Sepah; Daniel Ferraz; Mohamed Ibrahim; Raafay Sophie; Mehreen Ansari; Quan Dong Nguyen
Author Affiliations & Notes
  • Hongting Liu
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Millena Bittencourt
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Owhofasa Agbedia
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Ahmadreza Moradi
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Yasir Sepah
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Daniel Ferraz
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Mohamed Ibrahim
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Raafay Sophie
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Mehreen Ansari
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Quan Dong Nguyen
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships Hongting Liu, None; Millena Bittencourt, None; Owhofasa Agbedia, None; Ahmadreza Moradi, None; Yasir Sepah, None; Daniel Ferraz, None; Mohamed Ibrahim, None; Raafay Sophie, None; Mehreen Ansari, None; Quan Dong Nguyen, Genentech (F), Regeneron (F), Lux Biosciences (F), Abbott (F), GSK (F), Santen (F), Santen (C), Bausch and Lomb (C), Optos (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5026. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Longitudinal Changes in Retinal Sensitivity among Patients with Maculopathy
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      Hongting Liu, Millena Bittencourt, Owhofasa Agbedia, Ahmadreza Moradi, Yasir Sepah, Daniel Ferraz, Mohamed Ibrahim, Raafay Sophie, Mehreen Ansari, Quan Dong Nguyen; Longitudinal Changes in Retinal Sensitivity among Patients with Maculopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5026.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract
 
Purpose
 

To investigate longitudinal changes in retinal sensitivity among patients with maculopathy with stable visual acuity (VA) and central retinal thickness (CRT).

 
Methods
 

In this prospective study,16 patients with maculopathy and no change in VA (≤ 5 letters change in ETDRS score) and CRT (≤ 20 μm in spectral-domain optical coherence tomography (SD-OCT)) between 2 visits (interval: 2-6 months) were evaluated. Disease entities included diabetic macular edema, age related macular degeneration, central serous retinopathy, Stargardt's disease and idiopathic macular hole. Retinal sensitivity was assessed using the Spectral-OCT/SLO microperimetry (MP) (Optos Inc, Scotland, UK) at both visits. The test pattern was a standardized polar 3 grid which consists of 28 points within 11° from the fovea. The mean change and variance in retinal sensitivity for all patients was compared to the MP inter-session variation of 10 patients with retinopathies.

 
Results
 

A total of 700 points from 25 eyes (16 patients) with maculopathy were analyzed. The mean age of subjects was 53 years (SD ±16). The results are summarized in the table. The overall variance between the two visits (6.0dB) was significantly greater than the inter-session variance (2.4dB) (Mann Whitney Test, p=0.008).

 
Conclusions
 

Microperimetry may capture subtle functional changes in maculopathy patients with stable visual acuity and no change in central retinal thickness. Further studies with larger sample size are indicated to validate the observed results.

 
Image not available
View OriginalDownload Slide
Image not available
View OriginalDownload Slide
 
Keywords: 585 macula/fovea • 754 visual acuity • 642 perimetry  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept