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Ruth Hogg, George Murphy, Giovanni Staurenghi, Chiara Rosina, Rufino Silva, Ana Rita Santos, Usha Chakravarthy, Early Markers Observational Study.; Relationship between Visual Function and Optical Coherence Tomography features in Early Age-related macular degeneration (AMD)-Early Markers Observational Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5028. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between visual function parameters and tomographic metrics.
Study sample: 105 patients (53 males, 52 females) with unilateral advanced AMD from 3 Centres (Milan, Coimbra and Belfast) aged 52-93 years. Study Eye=Fellow eye without advanced neovascular disease. Best corrected distance acuity (BCVA) and near acuity (NVA), reading speed adjusted for print size (reading index; RI) and low-luminance acuity (SKILL test) were measured. High density macular raster scans on the Heidelberg were obtained. Trained graders measured the neuroretinal thickness (NRT) and choroidal thickness (CT) at the foveal centre and evaluated the continuity of the following layers (ganglion cell layer GCL, inner segment/outer segment junction IS/OS, external limiting membrane ELM, photoreceptor layer PRL and retinal pigment epithelium RPE). Univariate and logistic regression analyses were employed to examine relationships between function and morphology.
NRT was associated with BCVA (r=0.24 p=0.024); CT with reduced (SKILL score) (r=-0.4 p<0.001). Retinal layer continuity showed relationships with functional tests. External Limiting Membrane continuity was associated with DVA (p=0.006), NVA (p=0.021) and Reading index (p=0.020). IS/OS junction continuity was associated with DVA (p=0.007), NVA (p=0.03) and SKILL score (p=0.050). Photoreceptor layer continuity was associated with Reading index (p=0.039). RPE layer continuity was associated with SKILL score (p=0.003).
Significant associations exist between stressors of macular visual function such as near acuity and low luminance acuity and tomographic markers of retinal and choroidal morphology.
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