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Florian Sulzbacher, Christopher Kiss, Stefan Sacu, Marion Munk, Alexandra Kaider, Tamara Mittermueller, Philipp Roberts, Ursula Schmidt-Erfurth; The functional impact of subfoveal SD-OCT characteristic on reading acuity in neovascular age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5031.
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To correlate reading acuity in patients with neovascular age-related macular degeneration (nAMD) to specific SD-OCT characteristics of the subfoveal area.
Fourty four eyes showing untreated nAMD were examined with the Heidelberg Spectralis-OCT. Pateints’ reading acuity (logRAD) was assessed using a German language reading test (Radner Lesetest), visual acuity (logMAR) was assessed using EDTRS charts. Reading- and visual performance was evaluated with respect to the following OCT-findings in the subfoveal area 500x500µm: neovascular complex (NVC), fibrovascular pigment epithelium detachment (fPED), serous pigment epithelium detachment (sPED), subretinal fluid (SRF), intraretinal fluid (IRF) and intraretinal cysts (IRC).
Of 44 eyes with nAMD mean reading acuity in logRAD was 0.72 ± 0.3 and mean visual acuity in logMAR was 0.59 ± 0.28 showing a strong correlation of r=0.821 spearmen (P=0,000). In general, in subfoveal NVC, the mean logRAD score was 0.84 ± 0.24, whereas in NVC with additional cysts the mean logRAD score was 1.0 ± 0.18. With SRF, the mean logRAD was 0.58 ± 0.32, whereas with IRF the mean logRAD was measured at 0.70 ± 0.35. A SPED was associated with a mean logRAD score of 0.37 ± 0.10, a FPED was associated with 0.83 ± 0.26 and FPED with additional cyst revealed a mean logRAD score of 0.92 ± 0.28.
In nAMD, a severe deficiency in reading acuity was observed especially with subfoveal NVC associated with additional cysts and fibrovascular PED overlying cysts. Morphologic changes of the central retina have a direct impact on reading ability.
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