June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Racial variation in deep optic nerve head structures visualized with SD-OCT
Author Affiliations & Notes
  • Kulawan Rojananuangnit
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • John Johnstone
    Computer and Information Sciences, University of Alabama at Birmingham, Birmingham, AL
  • Massimo Fazio
    Center of Ocular Biomechanics and Biotransport, University of Alabama at Birmingham, Birmingham, AL
  • Mark Clark
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Cynthia Owsley
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Brandon Smith
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Christopher Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Footnotes
    Commercial Relationships Kulawan Rojananuangnit, None; John Johnstone, None; Massimo Fazio, None; Mark Clark, None; Cynthia Owsley, Genentech (F), Patent Licensed to: MacuLogix (P), Allergan (R); Brandon Smith, None; Christopher Girkin, SOLX (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 51. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kulawan Rojananuangnit, John Johnstone, Massimo Fazio, Mark Clark, Cynthia Owsley, Brandon Smith, Christopher Girkin; Racial variation in deep optic nerve head structures visualized with SD-OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):51. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To determine associations between variations in optic nerve head connective tissue visible with SD-OCT images with both age and race [African descent (AD), European Descent (ED)].

 
Methods
 

SD-OCT images from 171 normal eyes (66 eyes from 34 AD and 105 eyes from 53 ED) were included. 3D optic nerve head reconstructions were obtained. Delineation of the SD-OCT images was done using Devers Eye Institute Multiview software in 24 radial sagittal sections (Burgoyne C). A best fitting ellipse was computed using principal component analysis to define Bruch’s Membrane Opening (BMO) and this was taken as a reference for further analysis. A mesh was reconstructed from the point cloud for the anterior surface of lamina cribrosa (LC) and internal limiting membrane (ILM). We then measured the distance from a uniform sampling of the BMO ellipse to the LC mesh and ILM and calculated the mean and maximum depths for the lamina cribrosa depth (LCD; distance from BMO reference to LC mesh) and the cup depth (CD; distance from BMO reference to ILM). We looked at the variation in CD and LCD across racial strata (ED or AD) adjusted for age, central corneal thickness (CCT), axial length, and BMO area using mixed effects models with generalized estimating equations.

 
Results
 

The AD group showed larger disc area (2.1±0.5, 1.8±0.3 mm2, p<0.0001) and deeper cup depth (p value: 0.046) than the ED group after adjusted for all relevant confounds. (Table 1)

 
Conclusions
 

Increased cup depth as defined by the optic nerve surface tissues differed between AD and ED subjects, however, there was no significant difference in laminar cribrosa depth, suggesting these differences are largely due to difference in overlying pre-laminar surface tissues.

  
Keywords: 550 imaging/image analysis: clinical • 577 lamina cribrosa • 627 optic disc  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×