June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Antimicrobial Efficacy of New Investigational Multipurpose Disinfecting Solution and Comparison to Commercially Available Multipurpose Disinfecting Solutions
Author Affiliations & Notes
  • Marina Milenkovic
    Corneal R&D Microbiology, Abbott Medical Optics, Santa Ana, CA
  • Nancy Brady
    Corneal R&D Microbiology, Abbott Medical Optics, Santa Ana, CA
  • Anthony Lam
    Corneal R&D Microbiology, Abbott Medical Optics, Santa Ana, CA
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 516. doi:
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      Marina Milenkovic, Nancy Brady, Anthony Lam; Antimicrobial Efficacy of New Investigational Multipurpose Disinfecting Solution and Comparison to Commercially Available Multipurpose Disinfecting Solutions. Invest. Ophthalmol. Vis. Sci. 2013;54(15):516.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate antimicrobial efficacy of investigational multipurpose formulation against bacteria, fungi and Acanthamoeba spp. and compare it to commercially available multipurpose disinfecting solutions (MPS). Study was done according to ISO 14729:2001/A.2010 standard.

Methods: The multipurpose disinfecting solutions studied were - Investigational MPS-1: polyhexamethylene biguanide (PHMB) + poloxamer (PLX) and currently marketed Japan products MPS-2: polyquaternium (PQ1) + tetronic 1304, MPS-3: PHMB + poloxamine (PLA) and MPS-4: PHMB +PLX. Test organisms were: Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 9027), Serratia marcescens (ATCC 13880), Candida albicans (ATCC 10231), Fusarium solani (ATCC 36031) and Gram-negative clinical isolates. Test solutions were evaluated at the minimum recommended disinfection time of 4 hours. Disinfectant efficacy of MPS was also evaluated against Acanthamoeba trophozoites.

Results: After 4 hours exposure, Investigational MPS-1 and MPS-3 showed >3 log kill of ISO bacteria and fungi. MPS-2 and MPS-4 failed to meet stand-alone criteria for ISO bacteria and fungi. MPS-1, MPS-3 and MPS-4 showed >3 log kill against clinical isolates, while MPS-2 showed <1 log kill. MPS-1 and MPS-3 achieved >3 log reduction for Acanthamoeba trophozoites, while MPS-4 achieved <2 log reduction and MPS-2 achieved <1 log reduction.

Conclusions: New Investigational MPS-1 exhibited broad antimicrobial activity against ISO panel organisms and showed additional robustness against clinical isolates and Acanthamoeba trophozoites. MPS-1 showed similar activity as MPS-3, while MPS-2 and MPS-4 failed to meet stand-alone criteria against ISO organisms and clinical isolates.

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