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Zvi Kresch, Cynthia Yang, Vicente Diaz, Sanjay Kedhar, John Mauro, C. Michael Samson; Etiology of Non-infectious Uveitis Following Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5186.
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Investigated the etiology of new-onset non-infectious uveitis in patients that presented after cataract extraction and intraocular lens (IOL) implantation. While it is critical to rule out infectious etiologies, there are multiple other common causes for uveitis in this setting. These include: lens-induced uveitis, IOL-related inflammation and non-surgery related causes of inflammation.
Studied a cohort of patients that presented over a one-year period to two uveitis specialists at New York Eye and Ear Infirmary. Most patients received a work-up for complete blood count (CBC), Sedimentation rate, anti-nuclear antibody (ANA), Rheumatoid Factor (RF), Anti-neutrophil cytoplasmic antibody (ANCA), HLA-B27, syphilis serology and ultrasound biomicroscopy (UBM). Of forty-three patients seen, twelve were excluded due to other known causes of uveitis or evidence of other unrelated causes of uveitis. The remaining patients (31) were examined for age, sex, time from cataract surgery to uveitis onset, unilateral vs bilateral, location of uveitis and positive labwork or UBM.
There were a total of 31 patients that met the non-infectious uveitis following surgery criteria. 9/31 (29%) were male, 22/31 (71%) were female. Mean age at presentation was 68.6 years (range 47 - 92 years old). Location of uveitis was anterior in 30/31 (96.8%) and posterior in 1/31 (3.2%). In 21/31 (68%) the uveitis involved just the surgical eye and 10/31 (32%) were bilateral. 15/31 (48%) were idiopathic, of the remaining patients: 5/31 (16%) were due to lens position, 3/31 (9.6%) were ANA positive, 3/31 (9.6%) were RF positive, 3/31 (9.6%) were HLA-B27 positive, 1/31 (3.2%) was ANCA postive, 1/31 (3.2%) was biopsy proven Sarcoid, 1/31 (3.2%) was due to retained cortex.
This study examined common causes for new-onset non-infectious uveitis following cataract surgery. While approximately half of the cases were idiopathic, the other half were found to have a diagnosed etiology. These are important to consider as the treatment approach is very different from one cause to another. These results will help ophthalmologists be aware of some of the common non-infectious causes of uveitis following cataract surgery.
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