June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Segmentation and Analysis of Retinal Layers in Eyes with Uveitis and Comparison with Normal
Author Affiliations & Notes
  • Syed Mahmood Shah
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Yasir Sepah
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Mohammad Sadiq
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Saleema Kherani
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Mohamed Ibrahim
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Zubir Rentiya
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Mehreen Ansari
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Diana Do
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships Syed Mahmood Shah, None; Yasir Sepah, None; Mohammad Sadiq, None; Saleema Kherani, None; Mohamed Ibrahim, None; Zubir Rentiya, None; Mehreen Ansari, None; Diana Do, Genentech (F), Regeneron (F); Quan Dong Nguyen, Genentech (F), Regeneron (F), Lux Biosciences (F), Abbott (F), GSK (F), Santen (F), Santen (C), Bausch and Lomb (C), Optos (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5205. doi:https://doi.org/
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      Syed Mahmood Shah, Yasir Sepah, Mohammad Sadiq, Saleema Kherani, Mohamed Ibrahim, Zubir Rentiya, Mehreen Ansari, Diana Do, Quan Dong Nguyen; Segmentation and Analysis of Retinal Layers in Eyes with Uveitis and Comparison with Normal. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5205. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To examine the change in thickness of different retinal layers in eyes with intermediate (I), posterior (P) and panuveitis (Pan) Uveitis (U) in comparison to eyes with no known retinal disease.

 
Methods
 

This was a cross-sectional study. High-resolution 5 mm horizontal line scan passing through the fovea was acquired from 26 eyes with uveitis using Spectral Domain Optical Coherence Tomography. Eyes with macular edema and anterior uveitis were excluded from the analysis. Retinal layers were segmented to allow calculation of average thickness of retinal pigment epithelium (RPE), photoreceptor layer (PRL), bipolar cell layer (BPL), and combined ganglion cell and nerve fiber layers (GCL-NFL). Spatial changes in layers’ thicknesses and contribution of each layer to full retinal thickness (FRT) were assessed in 0.5mm increments. The measured values were compared to those from 50 normal eyes with no known retinal disease (Ibrahim et al., ARVO 2012).

 
Results
 

Four patients contributed both eyes and 18 had one eye included in the analysis. In 44% of the PU eyes decrease in FRT was observed (p=<0.05) primarily in RPE (44%), PRL (31%) and GCL/NFL (37%). Sixty percent of the IU eyes showed increase in FRT (p<0.05), primarily in the BPL (50%) and GCL/NFL (42%). Fewer PU eyes (6.2%) showed an increase in FRT, primarily localized to the BPL. See Figure 1/Table 1 for percentages (%) of eyes with significant thinning/thickening in the individual retinal layers in patients with uveitis.

 
Conclusions
 

Compared to normal eyes, eyes with IU had thickening mainly in the BPL and GCL/NFL, while eyes with panuveitis had thickening across PRL, BPL, and GCL/NFL. Eyes with posterior uveitis had overall decrease in retinal thickness, mainly due to attenuation in RPE, PRL, and GCL/NFL. Segmenting individual retinal layers may allow better understanding of the inflammatory process in different layers of the retina.

  
Keywords: 550 imaging/image analysis: clinical • 746 uveitis-clinical/animal model • 688 retina  
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