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Yakup Aksoy, Uzeyir Erdem; AUTOLOGOUS PLATELET RICH PLASMA THERAPY IN RESISTANT CORNEAL ULCERS. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5230.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the results and the application procedures of the platelet rich plasma therapy which is a novel option in resistant corneal ulcers?
We performed limited debridement after harvesting adequate samples from the margin of the lesions for culture and HSV PCR in nine eyes of the eight corneal ulcer sterile patients who had a history of resistant corneal ulcer one or more year inconclusive trials of various therapies. After the debridement all eyes administered autologous platelet rich plasma (8 drops/day).
Corneal ulcers of all cases were healed in about 4,3(±2,3) weeks. Visual acuity improvement was 4,1(±2,4) lines. In one case, epithelial defect relapsed after six months but, healed in 3 weeks again using the same protocol. we also applied wet PTK in 4 eyes after the treatment period.
We found that autologous platelet rich plasma therapy is effective in resistant corneal ulcers as an adjunctive therapy. Further investigations should be done in wider and different case series to prove its benefits in resistant corneal ulcers and also in different clinical applications.
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