Abstract
Purpose:
To evaluate the change in corneal endothelial cell density after transepithelial collagen cross-linking (CXL) for the treatment of corneal ectasia.
Methods:
Transepithelial CXL was performed using riboflavin 0.1% followed by UV-A light for 30 minutes in patients with keratoconus, pellucid degeneration, or LASIK-induced ectasia. Only eyes with corneal thickness greater than or equal to 400µm were treated. Endothelial cell counts were measured pre-CXL and at least 6 months post-CXL using noncontact specular microscopy.
Results:
Seventy three eyes were evaluated. The mean corneal endothelial cell density was 2522 +/- 513 cells/mm2 pre-CXL and 2674 +/- 452 cells/mm2 post-CXL (P=0.063).
Conclusions:
This study showed no significant change in corneal endothelial cell density after transepithelial CXL by riboflavin/ultraviolet-A treatment for corneal ectasia.
Keywords: 574 keratoconus •
481 cornea: endothelium