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Johnny Javier Castellar Cerpa, Jorge E. Peraza Nieves, Ricardo Cuiña Sardiña, David Diaz-Valle, Rosalía Mendez, Javier García Bella, José Ignacio Fernández-Vigo, Jose Benitez-del-Castillo; Accelerated cross-linking in patients with keratoconus: 6 months follow-up. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5271.
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To determine the effectiveness of accelerated cross-linking in patients with keratoconus, during six months of follow up, analyzing changes in visual acuity (VA), intraocular pressure (IOP), objective scatter index (OSI), corneal hysteresis (CH), and corneal resistance factor (CRF).
We performed a prospective descriptive study in 10 eyes with progressive keratoconus, that underwent accelerated cross-linking (Avedro). The studied variables were: uncorrected VA (UCVA), best corrected VA (BCVA) (measured with ETDRS test), IOP (determined with different tonometers: Perkins, Tonopen, and iCare), OSI (by ORA), CH and CRF (measured with Ocular Response Analyzer). Eyes were also assessed with Scheimpflug corneal topographer (Pentacam) measuring maximun keratometry (Kmax), medium keratometry (Km), thinnest point of the cornea, and RMS. The statistical study was performed with Statgraphics 5.1 by comparing paired groups and using the Wilcoxon signed range test.
At 6 months of follow-up no significant differences were found in the corneal topographic analysis, OSI and IOP. We also did not find a statistically significant decrease in corneal hysteresis and corneal resistance factor.
Control preoperative and postoperative accelerated cross-linking treatment, have shown no statistically significant progression of keratoconus after six month follow-up, probably related with changes in corneal biomechanic. It is necessary to continue the follow-up with more eyes during more time to confirm these findings.
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