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Luiz Felipe Moraes, Luciene Barbosa, Monique Macedo, Tatiana Rayes; ANALYSIS OF THICKNESS OF CORNEAS FROM EYE BANKS AFTER APPLICATION OF ISOSMOLAR RIBOFLAVIN AND HIPOSMOLAR RIBOFLAVIN. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5285.
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© ARVO (1962-2015); The Authors (2016-present)
Compare thickness of corneas from eye banks with 200mOsm and 400mOsm riboflavin.
Corneas placed in artificial chamber had pachymetry with epithelium, without epithelium and 30 minutes after application of anything (group 1-control); isosmolar (0,1% 400mOsm) riboflavin (group 2); hiposmolar (0,1% 200mOsm) riboflavin (group 3) and saline solution (group 4).
72 corneas were used; average prior pachymetry was 592μm and 548,8μm after removal of the epithelium. Group 1, 2 and 3 had decrease in thickness and group 4 had an increase. The average decrease in group 2 was 68,95μm, more than twice the average of group 3 (31,45μm).
Hiposmolar riboflavin prevents the decrease in thickness when compared to isoosmolar riboflavin.
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