June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Anterior-segment OCT epithelial mapping in early and advanced keratoconic eyes
Author Affiliations & Notes
  • Feilin Zhu
    Ophthalmology, NYU Medical Center, New York, NY
  • A. John Kanellopoulos
    Ophthalmology, NYU Medical Center, New York, NY
    Laservision Eye Institute, Athens, Greece
  • George Asimellis
    Laservision Eye Institute, Athens, Greece
  • Footnotes
    Commercial Relationships Feilin Zhu, None; A. John Kanellopoulos, Alcon Laboratories, Inc. (C), Avedro (C), Bausch and Lomb (C), Ocular Therapeutix (C); George Asimellis, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5294. doi:
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    • Get Citation

      Feilin Zhu, A. John Kanellopoulos, George Asimellis; Anterior-segment OCT epithelial mapping in early and advanced keratoconic eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5294.

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      © ARVO (1962-2015); The Authors (2016-present)

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Safety and efficacy of anterior segment optical coherence tomography epithelial thickness mapping as an ectasia prognosis


Epithelial thickness mapping was studied with anterior-segment optical coherence tomography (AS OCT) and high-frequency ultrasound biomicroscopy (HF UBM). Comparative study was conducted in eyes in normal group (N), keratoconic group (KCN) and keratoconic eyes treated with collagen-cross linking group (K CXL).


Our study indicates substantial topographic variation in epithelium thickness in the KCN group, however, there was an overall thickening of the epithelium, particularly over the pupil center of the order of + 3 μm, while the mean epithelium thickness is on average + 1.1 μm compared to the N group. No statistically significant difference was found between the N group and the K CXL group in terms of overall epithelium thickness. This finding was more pronounced among younger patients, and in agreement with high-frequency ultrasound epithelium thickness imaging.


AS OCT and HF UBM epithelial imaging indicates that on average, epithelium thickness in the K group was thicker, possibly as a reaction to ectasia. This may aid in the sub-clinical screening, particularly among young patients.

Keywords: 574 keratoconus • 482 cornea: epithelium • 421 anterior segment  

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