June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Comparison of the Spectral Domain Optical Coherence Tomography Characteristics in Patients with Multifocal Choroiditis and Punctate Inner Choroidopathy
Author Affiliations & Notes
  • Roomasa Channa
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Jiangxia Wang
    Dana Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Mohamed Ibrahim
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Jeong Lee
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Daniel Ferraz
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Yasir Sepah
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Millena Bittencourt
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Raafay Sophie
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Elham Hatef Naimi
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Quan Dong Nguyen
    Retinal Imaging Research and Reading Center, Johns Hopkins University, Wilmer Eye Institute, Baltimore, MD
  • Footnotes
    Commercial Relationships Roomasa Channa, None; Jiangxia Wang, None; Mohamed Ibrahim, None; Jeong Lee, None; Daniel Ferraz, None; Yasir Sepah, None; Millena Bittencourt, None; Raafay Sophie, None; Elham Hatef Naimi, None; Quan Dong Nguyen, Genentech (F), Regeneron (F), Lux Biosciences (F), Abbott (F), GSK (F), Santen (F), Santen (C), Bausch and Lomb (C), Optos (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5375. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Roomasa Channa, Jiangxia Wang, Mohamed Ibrahim, Jeong Lee, Daniel Ferraz, Yasir Sepah, Millena Bittencourt, Raafay Sophie, Elham Hatef Naimi, Quan Dong Nguyen; Comparison of the Spectral Domain Optical Coherence Tomography Characteristics in Patients with Multifocal Choroiditis and Punctate Inner Choroidopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5375.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC) are posterior uveitic entities. Both diseases have retinal and choroidal changes on spectral domain optical coherence tomography (SD-OCT). In this study, we aimed to determine if PIC and MFC could be distinguished based on microstructural characteristics on SD-OCT.

Methods: Clinic charts and images of patients meeting the diagnosis of MFC or PIC were retrospectively reviewed in this cross-sectional study. Two masked graders independently evaluated lesions on SD-OCT for microstructural changes in retina or choroid, with arbitration by a senior grader in cases of disagreement. Retinal changes were identified in the retinal pigment epithelium (RPE) and photoreceptor inner-outer segment associated bands on SD-OCT (IS/OS). RPE changes were classified as RPE elevation or RPE disruption. IS/OS changes were classified as IS/OS disruption or IS/OS intact. Generalized linear latent and mixed models were used to compare the different diagnoses and the occurrences of particular characteristics on SD-OCT. The models have the random effects of eyes nested within patients to take into consideration the possible correlation between different lesions in the same eye and fellow eye of the same subject.

Results: Twenty-six lesions from 8 eyes of 6 patients were included in the study. Sixteen lesions (62%) were from eyes with MFC; 10 lesions (38%) were from eyes with PIC. RPE changes were observed in 11 of 16 MFC lesions (69%) compared to 10 of 10 PIC lesions (100%). RPE elevation was identified in 6 of 10 PIC lesions (60%) compared to 3 of 16 MFC lesions (19%) (p= 0.063; OR= 7.09). RPE disruption was identified in 4 of 10 PIC lesions (40%) compared to 8 of 16 MFC lesions (50%) (p=0.53, OR=0.43). IS/OS disruption was identified in 4 of 10 PIC lesions (40%) compared to 15 of 16 MFC lesions (94%) (p = 0.029, OR= 0.04).

Conclusions: IS/OS disruption was significantly more frequently observed in MFC lesions versus PIC lesions. Our findings suggest that the two uveitic diseases may have distinctive characteristic on SD-OCT, which may help to distinguish between them. Additional studies to analyze more lesions from a larger number of patients are indicated to support our novel findings.

Keywords: 550 imaging/image analysis: clinical • 648 photoreceptors  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×