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Shiao Wei Wong, P. Tyagi, K. Khan, S. Hewick, Lucia Kuffova; Clinical course of a cohort of patients with Punctate Inner Choroidopathy managed with different modalities of treatment in North Scotland. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5379.
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The purpose of this study was to describe the clinical course of patients with PIC who received different combinations of treatments including observation, immunosuppression, photodynamic therapy (PDT), argon laser photocoagulation and intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.
A total of 21 patients (24 eyes) with PIC were included in this study. Patients with clinical features suggesting neovascular membrane related to age related macular degeneration or high myopia (-6.00 diopter in affected eye) and with previous other ocular diagnoses were excluded. The following data was collected retrospectively which includes patient demographics (age, gender), presence of myopia, clinical presentation, ocular findings on slit-lamp examinations, episodes of occurrence of choroidal neovascular membrane (CNVM) in affected eye and different modalities of treatment patients received. The rate of recurrence of CNVM, baseline visual acuity and final visual acuity on the last follow up appointment were determined.
Of 21 patients (24 eyes), the mean age at diagnosis was 45 years. 19 (90.5%) female and 2 (9.5%) were male. 12 patients (57.1%) were myopic. Mean duration of follow-up was 70 (range 1 to 285) months. Treatment received- 1) None- 2 eyes (8.3%), 2) Immunosupression only- 4 (16.7%) eyes, 3) immunosupression + Anti-VEGF- 1 eye (4.2%), 4) immunosuppression + PDT- 7 eyes (29.2%), 5) immunosuppression + laser- 2 eyes (8.3%), 6) immunosuppression + Anti-VEGF + Photodynamic Therapy- 8 eyes (33.3%). 21 eyes (87.5%) developed CNVM and 19 eyes (79.2%) developed recurrence of CNVM. Throughout the follow up period, 5 eyes (20.8%) maintained vision and 7 eyes (25.9%) showed improvement of vision.
Due to variable course of PIC and availability of treatments, different combinations were given to achieve optimum outcome for patients in this study.
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